INT354072

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Context Info
Confidence 0.07
First Reported 2011
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.22
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cort, Pomc) signal transduction (Pomc) generation of precursor metabolites and energy (Pomc)
extracellular space (Pomc) cell-cell signaling (Pomc) cytoplasm (Pomc)
Cort (Mus musculus)
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 2 89.40 High High
depression 16 27.40 Quite Low
antagonist 34 20.64 Low Low
agonist 18 5.00 Very Low Very Low Very Low
medulla 12 5.00 Very Low Very Low Very Low
Hippocampus 8 5.00 Very Low Very Low Very Low
Catecholamine 6 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Morphine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 160 99.38 Very High Very High Very High
Targeted Disruption 120 99.08 Very High Very High Very High
Depression 20 27.40 Quite Low
Anxiety Disorder 16 26.84 Quite Low
Aggression 34 5.00 Very Low Very Low Very Low
Sprains And Strains 24 5.00 Very Low Very Low Very Low
Obesity 6 5.00 Very Low Very Low Very Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low
Hypoglycemia 6 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Table II, we find some acute and chronic stressors are not influenced by the loss of the Avpr1b (e.g. acute severe restraint), some have a reduced ACTH response only (e.g. acute forced swimming stress) and some have both a reduced ACTH and CORT response in Avpr1b KOs compared to wild types (e.g. acute and repeated novel environment stress).
CORT Regulation (response) of ACTH associated with stress
1) Confidence 0.07 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.74 Pain Relevance 0.03
The nature of stressors to which both ACTH and CORT, ACTH but not CORT and neither ACTH or CORT responses are reduced in Avpr1b KO mice does not fall into any existing classification of stress.
CORT Neg (neither) Regulation (responses) of ACTH associated with stress and targeted disruption
2) Confidence 0.03 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.47 Pain Relevance 0.04

General Comments

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