INT354075

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Context Info
Confidence 0.19
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.88
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avpr1b) extracellular space (Oxt) extracellular region (Oxt)
plasma membrane (Avpr1b) response to stress (Avpr1b) signal transducer activity (Avpr1b)
Anatomy Link Frequency
corticotrophs 1
Oxt (Mus musculus)
Avpr1b (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 17 54.96 Quite High
agonist 9 5.00 Very Low Very Low Very Low
depression 8 5.00 Very Low Very Low Very Low
medulla 6 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Catecholamine 3 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Morphine 1 5.00 Very Low Very Low Very Low
amygdala 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 60 98.68 Very High Very High Very High
Stress 80 57.32 Quite High
Attention Deficit Hyperactivity Disorder 2 56.92 Quite High
Aggression 17 5.00 Very Low Very Low Very Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Depression 10 5.00 Very Low Very Low Very Low
Anxiety Disorder 8 5.00 Very Low Very Low Very Low
Obesity 3 5.00 Very Low Very Low Very Low
Hypersensitivity 3 5.00 Very Low Very Low Very Low
Hypoglycemia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As Oxt at high concentrations can elicit ACTH release via the Avpr1b, and the Oxtr may be expressed in corticotrophs, it has been suggested that increased expression of Oxtrs may be a compensatory mechanism through which Avpr1b KO mice and Brattleboro rats can, to some degree, make up for the lack of Avpr1b/Avp-mediated ACTH release (Nakamura et al. 2008).
Oxt Positive_regulation (elicit) of Avpr1b in corticotrophs associated with targeted disruption
1) Confidence 0.19 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.88 Pain Relevance 0.03

General Comments

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