INT354200

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Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.79
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igfbp7) extracellular region (Igfbp7) cell adhesion (Igfbp7)
Igfbp7 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 16 91.00 High High
ASIC 60 90.16 High High
Inflammation 68 80.60 Quite High
Pain 52 70.44 Quite High
Neuronal excitability 12 57.48 Quite High
Serotonin 8 40.00 Quite Low
dorsal root ganglion 4 26.56 Quite Low
sodium channel 8 23.12 Low Low
Nerve growth factor 16 5.68 Low Low
IPN 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acidosis 56 100.00 Very High Very High Very High
Cv Unclassified Under Development 8 91.00 High High
INFLAMMATION 76 80.60 Quite High
Pain 48 70.44 Quite High
Coronary Artery Disease 8 49.20 Quite Low
Aids-related Complex 32 36.16 Quite Low
Ganglion Cysts 4 25.60 Quite Low
Inflammatory Pain 28 5.00 Very Low Very Low Very Low
Injury 12 5.00 Very Low Very Low Very Low
Infection 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test the synergic interaction between two factors (i.e., mild acidosis and AGM, or AGM and Ca2+ reduction) on ASIC3 currents, additional two-way ANOVA analyses were made (Figures 2 and 5, p < 0.05 was considered significant).
Negative_regulation (reduction) of AGM associated with acidosis
1) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.17 Pain Relevance 0.07
These results suggest that ASIC3 channels may be gated in vivo by the combined actions of reduced extracellular Ca2+, mild acidosis, and AGM through synergic interactions reported here.
Negative_regulation (reduced) of AGM associated with acidosis
2) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.19 Pain Relevance 0.09
As shown in Figure 5A, B, the presence of 10 mM extracellular Ca2+ completely abolished the AGM currents, whereas reducing Ca2+ significantly potentiated AGM-induced currents.
Negative_regulation (reducing) of AGM-induced
3) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.21 Pain Relevance 0.12
As shown in Figure 5A, B, the presence of 10 mM extracellular Ca2+ completely abolished the AGM currents, whereas reducing Ca2+ significantly potentiated AGM-induced currents.
Negative_regulation (abolished) of AGM
4) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.22 Pain Relevance 0.12

General Comments

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