INT354201

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 5.32
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igfbp7) extracellular region (Igfbp7) cell adhesion (Igfbp7)
Igfbp7 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 119 99.68 Very High Very High Very High
Pain 91 99.12 Very High Very High Very High
IPN 49 98.36 Very High Very High Very High
agonist 14 95.76 Very High Very High Very High
ASIC 105 92.20 High High
bradykinin 7 89.28 High High
Potency 7 88.12 High High
Serotonin 14 87.92 High High
Nerve growth factor 28 87.44 High High
Inflammatory mediators 7 86.08 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 133 99.68 Very High Very High Very High
Infection 21 99.68 Very High Very High Very High
Injury 21 99.24 Very High Very High Very High
Pain 84 99.12 Very High Very High Very High
Cancer 14 98.76 Very High Very High Very High
Inflammatory Pain 49 98.36 Very High Very High Very High
Acidosis 98 98.24 Very High Very High Very High
Aids-related Complex 56 96.56 Very High Very High Very High
Cv Unclassified Under Development 14 85.96 High High
Hematoma 7 77.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of AGM and polyamines are increased during infection, trauma, and cancer [31,32].
Positive_regulation (increased) of AGM associated with cancer, injury and infection
1) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.94 Pain Relevance 0.42
Similarly, levels of peripheral AGM and polyamines are elevated during infection, trauma, and cancer [31,32].
Positive_regulation (elevated) of AGM associated with cancer, injury and infection
2) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.88 Pain Relevance 0.38
It is, however, possible that AGM-induced ASIC3 channel activation was through the chelation of extracellular Ca2+ as observed with lactate [39,56] at neutral pH.
Spec (possible) Positive_regulation (activation) of AGM-induced
3) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.18 Pain Relevance 0.09
In this study, we further showed that AGM-induced activation of ASIC3 is profoundly potentiated by mild acidosis, hyperosmolarity, increased arachidonic acid (AA), or reduced extracellular Ca2+, conditions that occur during inflammation and many other pathophysiological processes [8,33-39].
Positive_regulation (activation) of AGM-induced associated with acidosis and inflammation
4) Confidence 0.33 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.98 Pain Relevance 0.42
Considering that both AGM production [31,32] and ASIC3 expression [51,52] are increased during inflammation, the positive synergy between H+ and AGM in activating ASIC3 channels adds a new level of complexity to the molecular events that can lead to inflammatory pain.
Positive_regulation (increased) of AGM associated with inflammation and ipn
5) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 1.20 Pain Relevance 1.03
We found that pH 7.0 significantly potentiated AGM response and the potentiation was always more than additive with pH reduction regardless the sequence of agonist application (Figure 2D, E), a characteristic that is opposite to the accelerated ASIC desensitization caused by pretreatment with acidic solution [36].
Positive_regulation (potentiated) of AGM associated with agonist and asic
6) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.65 Pain Relevance 0.28
AGM-induced ASIC3 channel activation was not through the chelation of extracellular Ca2+ as occurs with increased lactate, but rather through a direct interaction with the newly identified nonproton ligand sensing domain.
Positive_regulation (activation) of AGM-induced
7) Confidence 0.27 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC3017031 Disease Relevance 0.48 Pain Relevance 0.25

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