INT354202

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 8.29
Pain Relevance 5.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igfbp7) extracellular region (Igfbp7) cell adhesion (Igfbp7)
Anatomy Link Frequency
plasma 1
Igfbp7 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 44 99.68 Very High Very High Very High
Pain 143 99.52 Very High Very High Very High
Glutamate 11 99.20 Very High Very High Very High
Inflammation 187 99.16 Very High Very High Very High
IPN 77 98.36 Very High Very High Very High
Neuronal excitability 33 97.40 Very High Very High Very High
Potency 11 93.68 High High
ASIC 165 90.80 High High
bradykinin 11 89.28 High High
Serotonin 22 87.92 High High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 22 99.68 Very High Very High Very High
Acidosis 154 99.60 Very High Very High Very High
Pain 132 99.52 Very High Very High Very High
INFLAMMATION 209 99.16 Very High Very High Very High
Cancer 22 99.00 Very High Very High Very High
Injury 33 98.52 Very High Very High Very High
Infection 33 98.52 Very High Very High Very High
Inflammatory Pain 77 98.36 Very High Very High Very High
Myalgia 11 98.28 Very High Very High Very High
Aids-related Complex 88 87.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, AGM is detectable in human plasma and higher concentrations have been observed in depressed patients [43].
Gene_expression (detectable) of AGM in plasma
1) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.80 Pain Relevance 0.33
Considering that both AGM production [31,32] and ASIC3 expression [51,52] are increased during inflammation, the positive synergy between H+ and AGM in activating ASIC3 channels adds a new level of complexity to the molecular events that can lead to inflammatory pain.
Gene_expression (production) of AGM associated with inflammation and ipn
2) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 1.18 Pain Relevance 1.01
Interestingly, AGM evokes ASIC3-dependent pain-behavior in mice [10], suggesting that AGM-ASIC3 interaction may become functionally relevant under pathological conditions.


Gene_expression (evokes) of AGM associated with pain
3) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.85 Pain Relevance 0.39
ASIC3-expressing CHO cells were exposed to AGM and mild acidosis in the absence or presence of hyperosmolarity (Figure 3).
Gene_expression (exposed) of AGM associated with acidosis
4) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.74 Pain Relevance 0.43
Synergy between AGM and Hyperosmolarity
Gene_expression (Synergy) of AGM
5) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 1.20 Pain Relevance 0.92
Remarkably, a significant potentiation was observed even when AGM was applied at lower concentrations (~100 ?
Gene_expression (applied) of AGM
6) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.62 Pain Relevance 0.37
Synergy between AGM and Arachidonic Acid
Gene_expression (Synergy) of AGM
7) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.57 Pain Relevance 0.34
Considering that both AGM production [31,32] and ASIC3 expression [51,52] are increased during inflammation, the positive synergy between H+ and AGM in activating ASIC3 channels adds a new level of complexity to the molecular events that can lead to inflammatory pain.
Gene_expression (expression) of AGM associated with inflammation and ipn
8) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 1.19 Pain Relevance 1.02
Not only is it metabolically interconvertible with the amino acids proline and glutamate, but it also serves as a precursor for synthesis of protein, nitric oxide (NO), agmatine (AGM), polyamines, ornithine, and urea [11].
Gene_expression (synthesis) of AGM associated with glutamate
9) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.07 Pain Relevance 0.25
l solution (in 0.9% NaCl) containing either saline (0.9% NaCl only), or AGM (1 mM), or hyperosmolarity (H-Osm, 600 mosmol kg-1 with mannitol), or AA (10 ?
Gene_expression (containing) of AGM
10) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.15 Pain Relevance 0.09
Levels of AGM and polyamines are increased during infection, trauma, and cancer [31,32].
Gene_expression (Levels) of AGM associated with cancer, injury and infection
11) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.92 Pain Relevance 0.41

General Comments

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