INT354205

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.02
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igfbp7) extracellular region (Igfbp7) cell adhesion (Igfbp7)
Igfbp7 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 68 99.68 Very High Very High Very High
Pain 52 99.52 Very High Very High Very High
IPN 28 98.36 Very High Very High Very High
bradykinin 4 89.28 High High
Serotonin 8 87.92 High High
Nerve growth factor 16 87.44 High High
Inflammatory mediators 4 86.08 High High
ASIC 60 85.92 High High
nMDA receptor 4 84.04 Quite High
agonist 8 82.48 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 76 99.68 Very High Very High Very High
Infection 12 99.68 Very High Very High Very High
Pain 48 99.52 Very High Very High Very High
Injury 12 99.24 Very High Very High Very High
Cancer 8 98.76 Very High Very High Very High
Inflammatory Pain 28 98.36 Very High Very High Very High
Acidosis 56 92.72 High High
Aids-related Complex 32 89.52 High High
Hematoma 4 77.24 Quite High
Cv Unclassified Under Development 8 76.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Considering that both AGM production [31,32] and ASIC3 expression [51,52] are increased during inflammation, the positive synergy between H+ and AGM in activating ASIC3 channels adds a new level of complexity to the molecular events that can lead to inflammatory pain.
Positive_regulation (increased) of Gene_expression (production) of AGM associated with inflammation and ipn
1) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 1.20 Pain Relevance 1.03
Remarkably, a significant potentiation was observed even when AGM was applied at lower concentrations (~100 ?
Positive_regulation (concentrations) of Gene_expression (applied) of AGM
2) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.68 Pain Relevance 0.40
Considering that both AGM production [31,32] and ASIC3 expression [51,52] are increased during inflammation, the positive synergy between H+ and AGM in activating ASIC3 channels adds a new level of complexity to the molecular events that can lead to inflammatory pain.
Positive_regulation (increased) of Gene_expression (expression) of AGM associated with inflammation and ipn
3) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 1.20 Pain Relevance 1.03
Levels of AGM and polyamines are increased during infection, trauma, and cancer [31,32].
Positive_regulation (increased) of Gene_expression (Levels) of AGM associated with cancer, injury and infection
4) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.94 Pain Relevance 0.42

General Comments

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