INT354210

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Context Info
Confidence 0.27
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 3.91
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn3) extracellular space (Igfbp7) extracellular region (Igfbp7)
cell adhesion (Igfbp7) plasma membrane (Accn3) cytoplasm (Accn3)
Igfbp7 (Mus musculus)
Accn3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 78 99.20 Very High Very High Very High
addiction 6 99.16 Very High Very High Very High
Inflammation 102 94.24 High High
ASIC 90 84.40 Quite High
ischemia 24 83.04 Quite High
Potency 6 81.56 Quite High
IPN 42 62.72 Quite High
Inflammatory response 6 60.32 Quite High
Neuronal excitability 18 36.88 Quite Low
agonist 12 34.24 Quite Low
Disease Link Frequency Relevance Heat
Pain 72 99.20 Very High Very High Very High
Cancer 12 96.16 Very High Very High Very High
Injury 18 95.68 Very High Very High Very High
Infection 18 95.36 Very High Very High Very High
Acidosis 84 95.16 Very High Very High Very High
INFLAMMATION 114 94.24 High High
Cv Unclassified Under Development 12 83.04 Quite High
Inflammatory Pain 42 62.72 Quite High
Aids-related Complex 48 44.56 Quite Low
Coronary Artery Disease 12 28.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The extracellular Ca2+ concentration can decrease from a resting value of around 1.2-1.8 mM to values as low as 0.08 mM under certain conditions [38], suggesting that the signaling cascade induced by AGM-ASIC3 interaction might be markedly amplified under such conditions.
AGM Binding (interaction) of ASIC3
1) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.27 Pain Relevance 0.11
The extracellular Ca2+ concentration can decrease from a resting value of around 1.2-1.8 mM to values as low as 0.08 mM under certain conditions [38], suggesting that the signaling cascade induced by AGM-ASIC3 interaction might be markedly amplified under such conditions.
AGM Binding (interaction) of ASIC3
2) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.27 Pain Relevance 0.11
Interestingly, AGM evokes ASIC3-dependent pain-behavior in mice [10], suggesting that AGM-ASIC3 interaction may become functionally relevant under pathological conditions.


AGM Binding (interaction) of ASIC3 associated with pain
3) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.86 Pain Relevance 0.40
Interestingly, AGM evokes ASIC3-dependent pain-behavior in mice [10], suggesting that AGM-ASIC3 interaction may become functionally relevant under pathological conditions.


AGM Binding (interaction) of ASIC3 associated with pain
4) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.86 Pain Relevance 0.40
To understand the functional relevance of AGM-ASIC3 interaction, we examined the pH dependence of AGM action by applying graded pH to the CHO cell expressing ASIC3 channels, in the presence or absence of AGM (Figure 2A).
AGM Binding (interaction) of ASIC3 associated with addiction
5) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.83 Pain Relevance 0.31
To understand the functional relevance of AGM-ASIC3 interaction, we examined the pH dependence of AGM action by applying graded pH to the CHO cell expressing ASIC3 channels, in the presence or absence of AGM (Figure 2A).
AGM Binding (interaction) of ASIC3 associated with addiction
6) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.83 Pain Relevance 0.31

General Comments

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