INT354223

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.40
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Car2, Igfbp7) cytosol (Car2) extracellular region (Igfbp7)
lyase activity (Car2) cell adhesion (Igfbp7) cytoplasm (Car2)
Car2 (Mus musculus)
Igfbp7 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 8 90.12 High High
ASIC 30 89.28 High High
Inflammation 34 70.92 Quite High
Neuronal excitability 6 47.80 Quite Low
Pain 26 5.00 Very Low Very Low Very Low
IPN 14 5.00 Very Low Very Low Very Low
Nerve growth factor 8 5.00 Very Low Very Low Very Low
sodium channel 4 5.00 Very Low Very Low Very Low
Serotonin 4 5.00 Very Low Very Low Very Low
PcTx1 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acidosis 28 100.00 Very High Very High Very High
Cv Unclassified Under Development 4 90.12 High High
INFLAMMATION 38 70.92 Quite High
Coronary Artery Disease 4 39.52 Quite Low
Pain 24 5.00 Very Low Very Low Very Low
Aids-related Complex 16 5.00 Very Low Very Low Very Low
Inflammatory Pain 14 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, similar to GMQ [10], AGM-ASIC3 interaction is highly sensitive to altered extracellular Ca2+.
Ca2 Binding (interaction) of AGM
1) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.21 Pain Relevance 0.10
These results suggest that ASIC3 channels may be gated in vivo by the combined actions of reduced extracellular Ca2+, mild acidosis, and AGM through synergic interactions reported here.
Ca2 Binding (interactions) of AGM associated with acidosis
2) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.19 Pain Relevance 0.09

General Comments

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