INT354232

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.47
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry12) plasma membrane (P2ry12) signal transducer activity (P2ry12)
Anatomy Link Frequency
CNS glial cells 2
P2ry12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 36 100.00 Very High Very High Very High
Inflammation 144 99.68 Very High Very High Very High
Central nervous system 78 98.84 Very High Very High Very High
Snapping jaw 126 98.08 Very High Very High Very High
allodynia 24 98.00 Very High Very High Very High
antagonist 3 95.40 Very High Very High Very High
Dorsal horn 21 94.40 High High
Eae 33 93.16 High High
Peripheral nervous system 18 92.08 High High
trigeminal ganglion 117 85.68 High High
Disease Link Frequency Relevance Heat
Pain 66 100.00 Very High Very High Very High
INFLAMMATION 156 99.68 Very High Very High Very High
Hypersensitivity 12 99.00 Very High Very High Very High
Temporomandibular Joint Syndrome 126 98.08 Very High Very High Very High
Neuropathic Pain 48 98.00 Very High Very High Very High
Nervous System Injury 18 93.76 High High
Inflammatory Pain 30 93.16 High High
Ganglion Cysts 117 85.68 High High
Nociception 15 85.56 High High
Targeted Disruption 3 29.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is worth mentioning that in a different model of inflammatory pain (i.e., the injection of CFA in the hindpaw) the intraperitoneal administration of the P2Y12 receptor antagonist 2,2-dimethyl-propionic acid 3-(2-chloro-6-methylaminopurin-9-yl)-2-(2,2-dimethyl-propionyloxymethyl)-propylester (MRS2395) significantly alleviated the mechanical hypersensitivity [69], but authors did not evaluated the possible changes in P2Y12 receptor expression in their experimental model.
Neg (not) Spec (possible) Regulation (changes) of Gene_expression (expression) of P2Y12 associated with antagonist, eae and hypersensitivity
1) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.82 Pain Relevance 0.57
On this basis, we analyzed the possible changes of P2Y12 receptor expression in our inflammatory model.
Spec (possible) Regulation (changes) of Gene_expression (expression) of P2Y12 associated with inflammation
2) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.99 Pain Relevance 0.70
Taken together, these results demonstrate that the expression of the purinergic P2Y12 receptor, which has been implicated in some forms of pain sensations, is not modified in the subacute reaction of CNS glial cells to TMJ inflammation.


Neg (not) Regulation (modified) of Gene_expression (expression) of P2Y12 in CNS glial cells associated with pain, snapping jaw, inflammation and central nervous system
3) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.66 Pain Relevance 0.92

General Comments

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