INT354233

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.33
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry12) plasma membrane (P2ry12) signal transducer activity (P2ry12)
Anatomy Link Frequency
microglial cells 2
P2ry12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Snapping jaw 42 94.28 High High
Dorsal horn 7 91.60 High High
Central nervous system 26 88.52 High High
medulla 13 77.52 Quite High
fifth nerve 7 74.28 Quite High
Pain 12 64.08 Quite High
Peripheral nervous system 6 61.96 Quite High
Inflammation 48 57.36 Quite High
trigeminal ganglion 39 55.60 Quite High
Lasting pain 11 46.32 Quite Low
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 42 94.28 High High
Pain 22 64.08 Quite High
INFLAMMATION 52 57.36 Quite High
Ganglion Cysts 39 55.60 Quite High
Neuropathic Pain 16 38.52 Quite Low
Nervous System Injury 6 34.28 Quite Low
Inflammatory Pain 10 28.80 Quite Low
Nociception 5 26.08 Quite Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite the observed upregulation of Iba1 immunoreactivity and the morphological changes observed in microglial cells (see above), no increase in P2Y12 receptor immunoreactivity in the ipsilateral side of CFA-injected rats was observed in either the trigeminal subnucleus caudalis (p = 0.957 and p = 0.968 at 24 h and 72 h respectively; n = 7 animals) (Figure 8A-B) or in the cervical dorsal horn (p = 0.734 and p = 0.923 at 24 h and 72 h respectively; n = 7 animals) (Figure 8C-D).
Neg (no) Positive_regulation (increase) of Regulation (immunoreactivity) of P2Y12 in microglial cells associated with dorsal horn
1) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.33 Pain Relevance 0.68

General Comments

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