INT354249

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Mtap6, Ppp1r9b) cytoplasm (Mtap6, Ppp1r9b) cell differentiation (Ppp1r9b)
nucleoplasm (Ppp1r9b) Golgi apparatus (Mtap6) plasma membrane (Ppp1r9b)
Mtap6 (Mus musculus)
Ppp1r9b (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 8 99.40 Very High Very High Very High
Morphine 120 97.56 Very High Very High Very High
Spinal cord 9 68.68 Quite High
Dopamine 14 62.76 Quite High
Nucleus accumbens 3 53.60 Quite High
opiate 3 50.00 Quite Low
Hippocampus 7 29.00 Quite Low
Intracerebroventricular 1 23.68 Low Low
mu opioid receptor 18 9.60 Low Low
narcan 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 3 72.36 Quite High
Nociception 40 50.00 Quite Low
Neuroblastoma 1 24.16 Low Low
Cognitive Disorder 1 6.16 Low Low
Schizophrenia 4 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because STOP proteins directly alter spinophilin function and interaction with actin cytoskeleton [16,17], this suggests the elevated morphine receptor affinity to possibly result from an impaired receptor targeting at the membrane and/or recycling.
STOP Binding (interaction) of spinophilin associated with morphine
1) Confidence 0.24 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017033 Disease Relevance 0.07 Pain Relevance 0.67

General Comments

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