INT354254

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.25
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (FBF1) cytoplasm (FBF1)
Anatomy Link Frequency
endothelial cell 2
smooth muscle cell 2
FBF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 152 99.50 Very High Very High Very High
Serotonin 2 90.28 High High
headache 20 83.76 Quite High
antagonist 2 61.28 Quite High
substance P 32 31.04 Quite Low
depression 10 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Triptan 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Migraine Without Aura 16 99.76 Very High Very High Very High
Increased Venous Pressure Under Development 16 97.68 Very High Very High Very High
Headache 150 90.40 High High
Epilepsy 30 88.04 High High
Attention Deficit Hyperactivity Disorder 2 85.60 High High
Hypersensitivity 2 66.52 Quite High
Migraine With Aura 6 5.28 Low Low
Depression 10 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Thrombosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent study in patients with migraine without aura, showed an impaired FBF response to the NO donor SNP, leading the authors to the hypothesis that vascular smooth muscle cell function is impaired in migraine without aura [26].
Negative_regulation (impaired) of Regulation (response) of FBF in smooth muscle cell associated with migraine
1) Confidence 0.03 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 1.10 Pain Relevance 0.95
Compared to healthy controls, FBF response to acetylcholine was impaired, but as FBF response to SNP, i.e endothelial-independent vasodilation, was impaired while acetylcholine-induced release of NO was intact, the authors hypothesized that vascular smooth muscle cell, but not endothelial cell function is impaired in migraine without aura.
Negative_regulation (impaired) of Regulation (response) of FBF in endothelial cell associated with migraine and increased venous pressure under development
2) Confidence 0.03 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 1.15 Pain Relevance 0.72

General Comments

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