INT35431

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Context Info
Confidence 0.25
First Reported 1988
Last Reported 2007
Negated 1
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.33
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DFP (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 4 99.98 Very High Very High Very High
rapifen 5 99.48 Very High Very High Very High
Morphine 4 99.40 Very High Very High Very High
Opioid 5 88.96 High High
Pain 5 85.28 High High
Inflammation 2 78.60 Quite High
analgesia 1 75.00 Quite High
Antinociceptive 2 72.68 Quite High
opioid receptor 1 71.84 Quite High
antinociception 2 70.12 Quite High
Disease Link Frequency Relevance Heat
Iron Overload 18 99.48 Very High Very High Very High
Thalassemia 21 98.80 Very High Very High Very High
Toxicity 7 98.18 Very High Very High Very High
Pain 5 85.28 High High
Cancer 1 80.48 Quite High
Hepatitis 1 79.88 Quite High
INFLAMMATION 2 78.60 Quite High
Poisoning 2 75.00 Quite High
Drug Induced Neurotoxicity 1 68.68 Quite High
Heart Disease 4 41.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Table 2 summarizes the results of several publications which examined the effectiveness of various doses of DFP in lowering iron overload in thalassemia patients throughout the world.
Spec (examined) Regulation (effectiveness) of DFP associated with thalassemia and iron overload
1) Confidence 0.25 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376085 Disease Relevance 0.71 Pain Relevance 0.04
Treatment of DFP toxicity with atropine and pralidoxime reversed the effects on alfentanil locomotion but failed to alter DFP's action upon morphine or fentanyl locomotion.
Neg (failed) Regulation (alter) of DFP associated with rapifen, toxicity and morphine
2) Confidence 0.24 Published 1988 Journal Neurotoxicol Teratol Section Abstract Doc Link 3147363 Disease Relevance 0.31 Pain Relevance 1.20
The onset of analgesic effect in the DFP 25-mg, DFP 50-mg, and naproxen sodium 550-mg groups did not differ significantly.
Regulation (effect) of DFP associated with analgesic
3) Confidence 0.11 Published 1999 Journal Clin Ther Section Abstract Doc Link 10485502 Disease Relevance 0.31 Pain Relevance 0.72

General Comments

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