INT35435

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Context Info
Confidence 0.42
First Reported 1988
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.26
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Anatomy Link Frequency
coronary artery 4
plasma 2
Serpine1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 5 74.44 Quite High
depression 1 72.04 Quite High
Dismenorea 2 65.00 Quite High
cytokine 7 56.80 Quite High
chemokine 4 56.24 Quite High
metalloproteinase 6 33.76 Quite Low
ischemia 2 25.00 Low Low
adenocard 3 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 18 99.28 Very High Very High Very High
Coronary Artery Disease 18 98.16 Very High Very High Very High
Coronary Heart Disease 1 80.80 Quite High
Angina 5 74.44 Quite High
Depression 1 72.04 Quite High
Dysmenorrhea 2 65.00 Quite High
Disease 2 50.16 Quite High
Death 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low
Reprotox - General 1 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ramipril prior to thrombolysis attenuates the early increase of PAI-1 in patients with acute myocardial infarction.
Negative_regulation (attenuates) of Positive_regulation (increase) of PAI-1 associated with myocardial infarction
1) Confidence 0.42 Published 2002 Journal Thromb. Haemost. Section Title Doc Link 12195686 Disease Relevance 0.40 Pain Relevance 0.11
can stimulate PAI-1, inhibiting the protease degradation of the ECM.
Negative_regulation (inhibiting) of Positive_regulation (stimulate) of PAI-1
2) Confidence 0.34 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0.07 Pain Relevance 0.12
A decrease in the fibrinolytic potential, mainly due to an elevation of plasminogen activator inhibitor (PAI), has been described in patients with stable coronary artery disease and a previous myocardial infarction.
Negative_regulation (decrease) of Positive_regulation (elevation) of activator inhibitor in coronary artery associated with coronary artery disease and myocardial infarction
3) Confidence 0.17 Published 1988 Journal Thromb. Haemost. Section Abstract Doc Link 3149044 Disease Relevance 0.55 Pain Relevance 0.05
A decrease in the fibrinolytic potential, mainly due to an elevation of plasminogen activator inhibitor (PAI), has been described in patients with stable coronary artery disease and a previous myocardial infarction.
Negative_regulation (decrease) of Positive_regulation (elevation) of PAI in coronary artery associated with coronary artery disease and myocardial infarction
4) Confidence 0.14 Published 1988 Journal Thromb. Haemost. Section Abstract Doc Link 3149044 Disease Relevance 0.60 Pain Relevance 0.05
This reduction was associated with elevation of PAI-I activity and reduction of tPA activity, independent of changes in plasma insulin levels.
Negative_regulation (elevation) of Positive_regulation (elevation) of PAI-I in plasma
5) Confidence 0.04 Published 2002 Journal Endocr. Res. Section Abstract Doc Link 12489566 Disease Relevance 0.64 Pain Relevance 0.12

General Comments

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