INT354395

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Context Info
Confidence 0.47
First Reported 2011
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.79
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNFSF12, IL18) extracellular region (TNFSF12, IL18) cell differentiation (TNFSF12)
cell-cell signaling (IL18) cytoplasm (IL18) cytosol (IL18)
TNFSF12 (Homo sapiens)
IL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 115 99.00 Very High Very High Very High
Inflammation 40 93.36 High High
alcohol 10 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 40 93.36 High High
Necrosis 15 91.36 High High
Cancer 15 91.00 High High
Death 20 86.60 High High
Apoptosis 25 82.72 Quite High
Reprotox - General 3 10 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 10 5.00 Very Low Very Low Very Low
Myeloid Leukemia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore we investigated whether TWEAK regulates IL-18 expression or at the opposite if IL-18 acts on TWEAK expression.
TWEAK Spec (whether) Regulation (regulates) of Gene_expression (expression) of IL-18
1) Confidence 0.47 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0.57 Pain Relevance 0.10
Our immunohistochemistry and PCR results show that TWEAK doesn't act on IL-18 expression, but seems to control IL-18 related cytotoxicity on uNK cells when IL-18 is over-expressed.
TWEAK Regulation (act) of Gene_expression (expression) of IL-18
2) Confidence 0.47 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.12
We compared the expression of TWEAK and IL-18 under different stimulation to determine if TWEAK regulate IL-18 expression or be regulated by this cytokine.
TWEAK Spec (determine) Regulation (regulate) of Gene_expression (expression) of IL-18 associated with cytokine
3) Confidence 0.47 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.08
In order to verify whether TWEAK could counterbalance IL-18 cytotoxic effect on uNK cells, we quantified, in different culture conditions, the expression of two proteins: NKp46, which mediates uNK cells cytotoxic effects and TGF-?
TWEAK Regulation (counterbalance) of Gene_expression (effect) of IL-18
4) Confidence 0.26 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0.07 Pain Relevance 0.07
TWEAK doesn't act on IL-18 expression but seems to control IL-18 related cytotoxicity on uNK cells when IL-18 is over-expressed.
TWEAK Regulation (act) of Gene_expression (expression) of IL-18
5) Confidence 0.18 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3017546 Disease Relevance 0.15 Pain Relevance 0.08

General Comments

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