INT354455

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Context Info
Confidence 0.31
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.21
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il11, Tnf) extracellular region (Il11, Tnf) cell proliferation (Tnf)
signal transduction (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
macrophages 2
Il11 (Mus musculus)
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 58 100.00 Very High Very High Very High
Inflammatory response 6 100.00 Very High Very High Very High
rheumatoid arthritis 41 99.70 Very High Very High Very High
Inflammation 4 93.62 High High
Arthritis 2 54.56 Quite High
visual analogue scale 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 10 100.00 Very High Very High Very High
Rheumatoid Arthritis 42 99.70 Very High Very High Very High
Disease 29 93.80 High High
Arthritis 1 54.56 Quite High
Pain 6 5.00 Very Low Very Low Very Low
Arthropathy 2 5.00 Very Low Very Low Very Low
Leukemia 2 5.00 Very Low Very Low Very Low
Anaemia 1 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-6 is a cytokine that causes an acute inflammatory response, and it is well-documented that IL-6 plays a crucial role in the pathogenesis of various inflammatory diseases including RA.6,7 IL-11, one of the IL-6 family cytokines, is found in high concentrations in the synovial membrane, synovial fluid, and serum of patients with RA, and it is also thought to be involved in the pathogenesis of RA.21 According to studies where the immunological role of IL-11 in RA was examined, IL-11 was shown to mediate an anti-inflammatory response by inhibiting the activity of macrophages and thereby diminishing the production of proinflammatory cytokines, such as TNF-?
IL-11 Negative_regulation (diminishing) of Gene_expression (production) of TNF in macrophages associated with inflammatory response, inflammation, rheumatoid arthritis, disease and cytokine
1) Confidence 0.31 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 1.21 Pain Relevance 0.74

General Comments

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