INT35448

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Context Info
Confidence 0.57
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 5.28
Pain Relevance 3.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ALOX5) nuclear envelope (ALOX5) small molecule metabolic process (ALOX5)
oxidoreductase activity (ALOX5) nucleus (ALOX5) cytoplasm (ALOX5)
ALOX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
licofelone 97 99.64 Very High Very High Very High
Osteoarthritis 214 99.40 Very High Very High Very High
antagonist 37 98.08 Very High Very High Very High
cytokine 6 98.00 Very High Very High Very High
Inflammation 83 92.80 High High
cINOD 60 92.56 High High
agonist 42 92.24 High High
aspirin 15 86.36 High High
COX-2 inhibitor 20 83.36 Quite High
Inflammatory mediators 15 82.64 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 221 99.40 Very High Very High Very High
Cancer 113 97.04 Very High Very High Very High
Arthritis 16 95.76 Very High Very High Very High
Disease 36 94.64 High High
Breast Cancer 7 93.60 High High
INFLAMMATION 122 92.80 High High
Aging 7 92.56 High High
Apoptosis 156 90.96 High High
Lung Cancer 10 88.72 High High
Anaphylactic Hypersensitivity 1 87.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These mutations result in a decreased expression of the 5-LOX gene.
Negative_regulation (decreased) of Gene_expression (expression) of 5-LOX
1) Confidence 0.57 Published 2000 Journal Med. Hypotheses Section Abstract Doc Link 10790729 Disease Relevance 0.79 Pain Relevance 0.15
The 15-lipoxygenase from soya bean has been claimed to represent a rapid assay procedure for drugs and chemical agents that inhibit other lipoxygenase products (Kingston, 1981).
Negative_regulation (inhibit) of Gene_expression (products) of lipoxygenase
2) Confidence 0.43 Published 1983 Journal Br. J. Dermatol. Section Abstract Doc Link 6407509 Disease Relevance 0.24 Pain Relevance 0.20
In PLT, orpanoxin (100 mumols/l) inhibited formation of cyclo-oxygenase products (thromboxanes, prostaglandins, and 12-L-hydroxy-5,8,10-heptadecatrienoic acid) and increased synthesis of the lipoxygenase product, 12S-hydroxy-5,8-cis,10-trans,14-cis-eicosatetraenoic acid.
Negative_regulation (inhibited) of Gene_expression (synthesis) of lipoxygenase
3) Confidence 0.42 Published 1988 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 3152163 Disease Relevance 0.08 Pain Relevance 0.19
MK866 blocks the 5-lipoxygenase pathway of arachidonic acid
Negative_regulation (blocks) of Gene_expression (pathway) of 5-lipoxygenase
4) Confidence 0.41 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.30 Pain Relevance 0.12
RESULTS: For the first time, it was demonstrated that licofelone inhibited prostate cancer cell growth and significantly down-regulated COX-2 and 5-LOX expression.
Negative_regulation (inhibited) of Gene_expression (expression) of 5-LOX
5) Confidence 0.41 Published 2007 Journal Anticancer Res. Section Body Doc Link 17695530 Disease Relevance 0.09 Pain Relevance 0
When both the COX-2 and 5-LOX inhibitors were introduced, the COX-2 and 5-LOX pathways were shut off, and the majority of the flux went through the 15-LOX pathway.
Negative_regulation (inhibitors) of Gene_expression (introduced) of 5-LOX
6) Confidence 0.32 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1829479 Disease Relevance 0.32 Pain Relevance 0.33
M HNE to cultures lead to a switch to 5-LOX and FLAP mRNA expression, and consequently to LTB4 production.
Negative_regulation (switch) of Gene_expression (expression) of 5-LOX
7) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.25 Pain Relevance 0.13
expended by the pharmaceutical industry to produce inhibitors of FLAP, 5-LOX as
Negative_regulation (inhibitors) of Gene_expression (produce) of 5-LOX
8) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2631651 Disease Relevance 0.53 Pain Relevance 0.17
We measured the expression of the two key enzymes involved in LT production, 5-LO and FLAP (Figure 2).
Negative_regulation (measured) of Gene_expression (expression) of 5-LO
9) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.66 Pain Relevance 0.33
Indeed, selective inhibition of 5-LOX and LTB4 synthesis is associated with a reduced production of these cytokines in vitro (Rainsford et al 1996).
Negative_regulation (inhibition) of Gene_expression (synthesis) of 5-LOX associated with cytokine
10) Confidence 0.04 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684079 Disease Relevance 0.23 Pain Relevance 0.70
A recent study has demonstrated that, in in vivo experimental osteoarthritis, licofelone, a drug that can inhibit both the COX and 5-LOX pathways, was capable of reducing the development of osteoarthritis structural changes while simultaneously reducing the synthesis of LTB4 and IL-1?
Negative_regulation (inhibit) of Gene_expression (pathways) of 5-LOX associated with licofelone and osteoarthritis
11) Confidence 0.03 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684079 Disease Relevance 0.80 Pain Relevance 0.75

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