INT354480

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.96
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PRNP) endoplasmic reticulum (PRNP) nucleolus (PRNP)
plasma membrane (PRNP) nucleus (PRNP) cell cycle (PRNP)
PRNP (Homo sapiens)
Pain Link Frequency Relevance Heat
Demyelination 2 95.24 Very High Very High Very High
Action potential 2 73.68 Quite High
Central nervous system 8 36.84 Quite Low
iatrogenic 12 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 110 99.88 Very High Very High Very High
Creutzfeldt Jakob Disease 178 99.32 Very High Very High Very High
Demyelinating Disease 2 95.24 Very High Very High Very High
Cognitive Disorder 4 92.56 High High
Congenital Anomalies 4 90.20 High High
Disease 48 89.92 High High
Sprains And Strains 110 77.76 Quite High
Drug Induced Neurotoxicity 8 73.28 Quite High
Disease Progression 2 63.36 Quite High
Lifespan 2 50.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Very recently it has been revealed that axonal PrPC expression is required for peripheral myelin maintenance [154] and this finding correlates strongly with earlier demonstrations of extensive demyelination in transgenic mice expressing PrP with deletion mutants in the central domain [155–157].
Regulation (required) of Gene_expression (expression) of PrPC associated with targeted disruption and demyelination
1) Confidence 0.39 Published 2010 Journal Neuropathology and Applied Neurobiology Section Body Doc Link PMC3017745 Disease Relevance 1.13 Pain Relevance 0.08
Transgenic mice expressing human prion protein in the absence of endogenous mouse prion protein faithfully replicate human prions.
Regulation (absence) of Gene_expression (expressing) of prion protein associated with targeted disruption
2) Confidence 0.24 Published 2010 Journal Neuropathology and Applied Neurobiology Section Abstract Doc Link PMC3017745 Disease Relevance 0.82 Pain Relevance 0

General Comments

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