INT35450

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Context Info
Confidence 0.47
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.46
Pain Relevance 3.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Htr2a) signal transduction (Htr2a) cell death (Htr2a)
plasma membrane (Htr2a) response to stress (Htr2a) cytoplasm (Htr2a)
Anatomy Link Frequency
plasma 1
skin 1
Htr2a (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 72 100.00 Very High Very High Very High
Neuropathic pain 2 99.90 Very High Very High Very High
Hyperalgesia 1 99.48 Very High Very High Very High
Calcitonin gene-related peptide 7 99.46 Very High Very High Very High
substance P 9 99.24 Very High Very High Very High
antidepressant 89 99.08 Very High Very High Very High
Antinociceptive 3 98.56 Very High Very High Very High
fluoxetine 7 98.42 Very High Very High Very High
addiction 5 97.96 Very High Very High Very High
Nucleus accumbens 32 97.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 2 99.90 Very High Very High Very High
Stress 38 99.54 Very High Very High Very High
Hyperalgesia 1 99.48 Very High Very High Very High
Urological Neuroanatomy 4 95.20 Very High Very High Very High
Injury 2 93.48 High High
Apoptosis 1 91.08 High High
Nociception 6 89.64 High High
Inflammatory Pain 2 87.84 High High
Fatigue 2 85.24 High High
INFLAMMATION 6 81.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sex differences were detected in the number of 5-HT2 and mu receptors between male and female mice not subjected to stress, while the percentage decrease in 5-HT2 and mu receptors did not differ significantly between the two sexes.
Negative_regulation (decrease) of 5-HT2 associated with stress
1) Confidence 0.47 Published 2005 Journal Life Sci. Section Abstract Doc Link 15935399 Disease Relevance 0.97 Pain Relevance 0.30
Acute noise stress provoked an antinociceptive effect, associated with an increase in plasma corticosterone levels, a decrease in the number of 5-HT2 receptors in stressed male and female mice and a decrease in the number of mu receptors in both sexes.
Negative_regulation (decrease) of 5-HT2 in plasma associated with stress and antinociceptive
2) Confidence 0.47 Published 2005 Journal Life Sci. Section Abstract Doc Link 15935399 Disease Relevance 1.07 Pain Relevance 0.36
The Spearman rank correlation coefficient was used to test dependence between the cortisol ratios and number of PGP 9.5-, substance P-, and CGRP-positive nerve fibres and number of 5HT1AR, 5-HT2AR, SERT-positive cells and mast cells, respectively, in the involved and non-involved skin.
Negative_regulation (number) of 5-HT2AR in skin associated with addiction, calcitonin gene-related peptide and substance p
3) Confidence 0.42 Published 2008 Journal Journal of the European Academy of Dermatology and Venereology Section Body Doc Link PMC2229631 Disease Relevance 0.34 Pain Relevance 0.15
It was also shown that pretreatment with antagonists of 5HT1A and 5HT2A receptors antagonized antidepressant-like activity of SSRIs in the TST in mice (Miyata et al. 2004), suggesting that activation of both receptors plays a key role in the action of compounds acting via activation of the serotonergic system in this test.
Negative_regulation (antagonists) of 5HT2A associated with antidepressant, antagonist and ssri
4) Confidence 0.42 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0 Pain Relevance 0.69
The present placebo-controlled study with 24 healthy subjects was designed to answer the following questions: Does fluoxetine increase measures of cortical arousal and decrease feelings of alertness, and does the 5HT2 receptor blocker ritanserin produce inverse effects to fluoxetine?
Negative_regulation (does) of 5HT2 receptor associated with fluoxetine
5) Confidence 0.35 Published 1988 Journal Int Clin Psychopharmacol Section Abstract Doc Link 3155282 Disease Relevance 0.15 Pain Relevance 0.53
These results suggests sarpogrelate has a beneficial effect on hyperalgesia and neuropathic pain via inhibiting 5-HT2A receptor.
Negative_regulation (inhibiting) of 5-HT2A receptor associated with hyperalgesia and neuropathic pain
6) Confidence 0.11 Published 2001 Journal Nippon Rinsho Section Abstract Doc Link 11554035 Disease Relevance 0.94 Pain Relevance 0.86
The absence of DA release in the NAcc after acute MDMA (10 mg/kg) injection [19] and CPP after MDMA (10 mg/kg) conditioning indicates that mice lacking functional 5-HT2B receptor should not exhibit ERK activation with low dose of MDMA.
Negative_regulation (lacking) of 5-HT2B receptor associated with nucleus accumbens and dopamine
7) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775951 Disease Relevance 0 Pain Relevance 0.44

General Comments

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