INT35452

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Context Info
Confidence 0.65
First Reported 1988
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 5.11
Pain Relevance 6.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Htr2a) signal transduction (Htr2a) cell death (Htr2a)
plasma membrane (Htr2a) response to stress (Htr2a) cytoplasm (Htr2a)
Anatomy Link Frequency
primary neurons 1
spinal cord 1
brain 1
Htr2a (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 150 100.00 Very High Very High Very High
Kinase C 35 99.84 Very High Very High Very High
Spinal cord 10 99.80 Very High Very High Very High
depression 70 99.60 Very High Very High Very High
Multiple sclerosis 70 99.60 Very High Very High Very High
fluoxetine 8 99.20 Very High Very High Very High
Analgesic 17 98.48 Very High Very High Very High
Pain 35 98.32 Very High Very High Very High
Serotonin 555 98.08 Very High Very High Very High
antidepressant 188 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 72 99.60 Very High Very High Very High
Demyelinating Disease 70 99.60 Very High Very High Very High
Pain 35 98.32 Very High Very High Very High
Hypertrophic Cardiomyopathy 126 97.72 Very High Very High Very High
Left Ventricular Hypertrophy 57 96.12 Very High Very High Very High
Endometriosis (extended) 130 93.96 High High
Targeted Disruption 14 93.68 High High
Sleep Disorders 25 88.64 High High
Experimental Autoimmune Encephalomyelitis 5 87.28 High High
Fatigue 2 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 5HT2A/2C receptor antagonist, ritanserin (0.5 mg/kg), was not active in the TST when given alone, and it did not influence the MGS0039 (3 mg/kg)-induced attenuation of immobility time in the TST in mice [F(1,24)?
Neg (not) Gene_expression (active) of 5HT2A associated with antagonist
1) Confidence 0.65 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0 Pain Relevance 0.31
The 5HT2A/2C receptor antagonist, ritanserin (0.5 mg/kg), was not active in the TST when given by itself, and it did not influence the LY341495-induced attenuation of the immobility time in the TST in mice [F(1,27)?
Neg (not) Gene_expression (active) of 5HT2A associated with antagonist
2) Confidence 0.65 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0 Pain Relevance 0.45
The present placebo-controlled study with 24 healthy subjects was designed to answer the following questions: Does fluoxetine increase measures of cortical arousal and decrease feelings of alertness, and does the 5HT2 receptor blocker ritanserin produce inverse effects to fluoxetine?
Gene_expression (produce) of 5HT2 receptor associated with fluoxetine
3) Confidence 0.64 Published 1988 Journal Int Clin Psychopharmacol Section Abstract Doc Link 3155282 Disease Relevance 0.15 Pain Relevance 0.54
The genotyping of the 5-HT2A, 5-HTT, AGT, ACE, and AT1R polymorphisms showed a significantly higher frequency of carriers of the AT1R C allele (AC+CC genotypes) in the HCM patients without sarcomeric gene mutations compared to the healthy controls (p = 0.015; OR = 1.56; 95% CI = 1.09-2.23) (Table 2).
Gene_expression (genotyping) of 5-HT2A associated with hypertrophic cardiomyopathy
4) Confidence 0.20 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.81 Pain Relevance 0
We examined the difference for the main characteristics between the 5-HT2A, 5-HTT, AGT, ACE, and AT1R genotypes in the 205 patients without sarcomeric mutations.
Gene_expression (genotypes) of 5-HT2A
5) Confidence 0.20 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.62 Pain Relevance 0
The reference numbers for the five polymorphisms were: rs699 (AGT, c.803 T/C); rs6313 (5-HT2A, c.102 T/C); rs5186 (AT1R, c.1166 A/C); rs4646994 (ACE, intron 16 I/D); rs4795541 (5-HTT, promoter l/s) (see the Ensembl database for the definition of these gene variants; http://www.ensembl.org).
Gene_expression (rs6313) of 5-HT2A
6) Confidence 0.18 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.13 Pain Relevance 0.04
However, 5-HT2B receptor mRNA and protein are coexpressed in SERT-expressing primary neurons from mice raphé nuclei [18].
Gene_expression (coexpressed) of 5-HT2B receptor in primary neurons
7) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775951 Disease Relevance 0 Pain Relevance 0.64
Normal physiology depends on maintaining a balance between 5HT2A receptor produced Ca++ inflow and 5HT1A receptor suppression of cAMP production.
Gene_expression (produced) of 5HT2A receptor
8) Confidence 0.04 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.12 Pain Relevance 0.47
In women with depression around or following menopause, the effectiveness of treatment with selective serotonin reuptake inhibitors (SSRIs) is enhanced by simultaneous administration of estrogen,[63] and doses of estrogen alone are effective at treating premenstrual, postpartum, and perimenopausal depression, especially for depression linked to aberrant expression of 5HT2A receptors [25,66].
Gene_expression (expression) of 5HT2A associated with endometriosis (extended), depression and ssri
9) Confidence 0.03 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.95 Pain Relevance 0.78
In the spinal cord, altered expression of 5HT2A receptors can both increase and decrease pain [48,49].
Gene_expression (expression) of 5HT2A in spinal cord associated with pain and spinal cord
10) Confidence 0.03 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 1.11 Pain Relevance 1.49
Gene-microarray analysis of brain lesions found lower 5HT2 receptor expression in all 4 MS patients that analysis was preformed for compared to that of 2 controls [120].
Gene_expression (expression) of 5HT2 receptor in brain associated with multiple sclerosis
11) Confidence 0.03 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 1.21 Pain Relevance 0.81
Following 5HT2A activation of PKC, 5HT1A receptors become unable to reduce serotonin production through negative feedback, and serotonin concentrations increase [32-34] E2 compounds this effect by directly inhibiting 5HT1A function [35,36].
Gene_expression (activation) of 5HT2A associated with kinase c and serotonin
12) Confidence 0.03 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0 Pain Relevance 0.57

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