INT35460

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Context Info
Confidence 0.75
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 45
Total Number 45
Disease Relevance 48.71
Pain Relevance 10.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL16) extracellular region (IL16) plasma membrane (IL16)
nucleus (IL16) intracellular (IL16) cytoplasm (IL16)
Anatomy Link Frequency
macrophages 4
mononuclear cells 3
eosinophils 2
cerebrospinal fluid 1
bowel 1
IL16 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 139 100.00 Very High Very High Very High
Inflammation 409 99.98 Very High Very High Very High
substance P 17 99.76 Very High Very High Very High
Crohn's disease 256 99.74 Very High Very High Very High
Enkephalin 56 99.74 Very High Very High Very High
Opioid 49 99.74 Very High Very High Very High
rheumatoid arthritis 121 99.60 Very High Very High Very High
Multiple sclerosis 33 96.64 Very High Very High Very High
Arthritis 37 85.52 High High
Inflammatory response 5 79.20 Quite High
Disease Link Frequency Relevance Heat
Disease 3339 100.00 Very High Very High Very High
INFLAMMATION 282 99.98 Very High Very High Very High
Cv Unclassified Under Development 333 99.82 Very High Very High Very High
Apoptosis 512 99.72 Very High Very High Very High
Neurologic Manifestations 297 99.64 Very High Very High Very High
Rheumatoid Arthritis 124 99.60 Very High Very High Very High
Rickettsiaceae Infection 132 99.56 Very High Very High Very High
Recurrence 433 99.54 Very High Very High Very High
Inflammatory Bowel Disease 426 99.36 Very High Very High Very High
Eczema 33 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, patients with ulcerative colitis exhibited very high levels of circulating nucleosomes as compared to patients with WD, but their circulating levels of IL-16 were similar to those of healthy controls.
Gene_expression (levels) of IL-16 associated with inflammatory bowel disease and disease
1) Confidence 0.75 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.46 Pain Relevance 0.09
Circulating levels of IL-16 and nucleosomes were similarly increased in patients with intestinal (Fig 2A and B), cardiac and neurological manifestations (Fig 2C and D).
Gene_expression (levels) of IL-16 associated with neurologic manifestations
2) Confidence 0.75 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.28 Pain Relevance 0.06
In addition, increased circulating levels of IL-16 and nucleosomes were specific to WD disease, not to the T. whipplei infection.
Gene_expression (levels) of IL-16 associated with disease and infection
3) Confidence 0.75 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.45 Pain Relevance 0.08
In contrast, patients with Crohn's disease or with Q fever endocarditis had low levels of IL-16 and nucleosomes.
Gene_expression (levels) of IL-16 associated with crohn's disease, cv unclassified under development, rickettsiaceae infection and disease
4) Confidence 0.75 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.61 Pain Relevance 0.09
Increased levels of both IL-16 and nucleosomes were specific to WD.
Gene_expression (levels) of IL-16 associated with disease
5) Confidence 0.75 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.38 Pain Relevance 0.10
Increased circulating levels of IL-16 and nucleosomes were specific to WD.
Gene_expression (levels) of IL-16 associated with disease
6) Confidence 0.75 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.40 Pain Relevance 0.07
Indeed, some patients with WD exhibited a high number of eosinophils [2], known to produce IL-16 [22], but the patients with hypereosinophilia did not exhibit higher levels of IL-16 (data not shown).
Gene_expression (produce) of IL-16 in eosinophils associated with disease
7) Confidence 0.75 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.51 Pain Relevance 0.13
Timed studies of the production of LCF over a 54-hr period showed that there was an appreciable lag in the onset of measurable LCF activity in mononuclear supernatants produced in the presence of beta-endorphin and met-enkephalin.
Gene_expression (production) of LCF associated with enkephalin
8) Confidence 0.70 Published 1985 Journal J. Immunol. Section Abstract Doc Link 3156934 Disease Relevance 0 Pain Relevance 0.86
Inhibition of LCF production was observed by using concentrations of 10(-11) to 10(-6) M beta-endorphin or met-enkephalin but not alpha-endorphin.
Gene_expression (production) of LCF associated with enkephalin
9) Confidence 0.70 Published 1985 Journal J. Immunol. Section Abstract Doc Link 3156934 Disease Relevance 0 Pain Relevance 0.65
Indeed, some patients with WD exhibited a high number of eosinophils [2], known to produce IL-16 [22], but the patients with hypereosinophilia did not exhibit higher levels of IL-16 (data not shown).
Gene_expression (levels) of IL-16 in eosinophils associated with disease
10) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.50 Pain Relevance 0.13
Antibiotic treatment decreased the circulating levels of IL-16 (Fig. 3A) and nucleosomes (Fig. 3B) in patients down to levels comparable to those found in control subjects, independently of the clinical manifestations of WD.
Gene_expression (levels) of IL-16 associated with disease
11) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 0.91 Pain Relevance 0
Circulating IL-16 and nucleosomes in treated WD patients
Gene_expression (nucleosomes) of IL-16 associated with disease
12) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 0.71 Pain Relevance 0
Although untreated patients with WD exhibited high circulating levels of IL-16 and nucleosomes, there was some heterogeneity in patients.
Gene_expression (levels) of IL-16 associated with disease
13) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.07 Pain Relevance 0
In relapsing patients with intestinal or neurological manifestations of WD, the circulating levels of IL-16 (Fig 3A) and nucleosomes (Fig 3B) were high and similar to those found in untreated patients with WD.
Gene_expression (levels) of IL-16 associated with disease and neurologic manifestations
14) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.01 Pain Relevance 0
Indeed, untreated patients with intestinal manifestations of WD exhibited significantly higher circulating levels of IL-16 than patients with ulcerative colitis (p<0.05) or Crohn's disease (p<0.01) (Fig 2A).
Gene_expression (levels) of IL-16 associated with inflammatory bowel disease, crohn's disease and disease
15) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.48 Pain Relevance 0.12
This finding was specific to WD since the circulating levels of IL-16 and nucleosomes were not increased in patients with unrelated inflammatory diseases such as inflammatory bowel disease or Q fever endocarditis.
Gene_expression (levels) of IL-16 in bowel associated with inflammation, cv unclassified under development, rickettsiaceae infection and disease
16) Confidence 0.58 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC1876813 Disease Relevance 1.71 Pain Relevance 0.10
The combination of increased levels of IL-16 and caspase 3 activity has been reported in cerebrospinal fluid from patients with multiple sclerosis and experimental autoimmune encephalomyelitis, and is correlated with disease activity [37], [38].
Gene_expression (levels) of IL-16 in cerebrospinal fluid associated with multiple sclerosis and disease
17) Confidence 0.58 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.63 Pain Relevance 0.10
Conversely, circulating IL-16 was increased in patients with WD (our results) and is produced by macrophages isolated from blood [16], but the expression of IL-16 is not increased in macrophages infiltrating intestinal lesions of one patient with WD [15], suggesting that IL-16 is associated with the systemic phase of WD.
Gene_expression (produced) of IL-16 in macrophages associated with disease
18) Confidence 0.58 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.61 Pain Relevance 0.18
As WD is characterized by different intestinal, cardiac or neurological manifestations, we asked if the levels of IL-16 and nucleosomes were related to the clinical manifestations of WD.
Gene_expression (levels) of IL-16 associated with disease and neurologic manifestations
19) Confidence 0.58 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.16 Pain Relevance 0.03
The presence of high circulating levels of IL-16 in WD could not be explained by the production of IL-16 by human macrophages stimulated by T. whipplei but evoked other cell types as a source for IL-16.
Gene_expression (source) of IL-16 in macrophages associated with disease
20) Confidence 0.58 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.53 Pain Relevance 0.14

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