INT35462

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Context Info
Confidence 0.53
First Reported 1985
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 2.04
Pain Relevance 6.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL16) extracellular region (IL16) plasma membrane (IL16)
nucleus (IL16) intracellular (IL16) cytoplasm (IL16)
Anatomy Link Frequency
mononuclear cells 6
PGE2 2
IL16 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 48 100.00 Very High Very High Very High
Enkephalin 56 99.76 Very High Very High Very High
Crohn's disease 14 47.44 Quite Low
Inflammation 14 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 198 99.98 Very High Very High Very High
Recurrence 26 97.92 Very High Very High Very High
Neurologic Manifestations 18 90.48 High High
Apoptosis 30 67.24 Quite High
Inflammatory Bowel Disease 20 49.92 Quite Low
Cv Unclassified Under Development 20 37.48 Quite Low
Bacterial Endocarditis 2 35.20 Quite Low
Rickettsiaceae Infection 8 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of LCF production was observed by using concentrations of 10(-11) to 10(-6) M beta-endorphin or met-enkephalin but not alpha-endorphin.
Negative_regulation (Inhibition) of Gene_expression (production) of LCF associated with enkephalin
1) Confidence 0.53 Published 1985 Journal J. Immunol. Section Abstract Doc Link 3156934 Disease Relevance 0 Pain Relevance 0.65
Although untreated patients with WD exhibited high circulating levels of IL-16 and nucleosomes, there was some heterogeneity in patients.
Negative_regulation (exhibited) of Gene_expression (levels) of IL-16 associated with disease
2) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 1.07 Pain Relevance 0
Antibiotic treatment decreased the circulating levels of IL-16 (Fig. 3A) and nucleosomes (Fig. 3B) in patients down to levels comparable to those found in control subjects, independently of the clinical manifestations of WD.
Negative_regulation (decreased) of Gene_expression (levels) of IL-16 associated with disease
3) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1876813 Disease Relevance 0.96 Pain Relevance 0
A bimodal pattern of suppression of LCF production was observed with both met-enkephalin and beta-endorphin when titrated from 10(-12) to 10(-6) M concentrations, with the peaks of suppressive activity occurring at concentrations of 10(-11) M and 10(-6) M.
Negative_regulation (suppression) of Gene_expression (production) of LCF associated with enkephalin
4) Confidence 0.39 Published 1985 Journal J. Immunol. Section Abstract Doc Link 3156934 Disease Relevance 0 Pain Relevance 0.77
The suppression of LCF production mediated by opioid peptides in mononuclear supernatants was abrogated by depletion of glass-adherent mononuclear cells before culturing with opioids and Con A.
Negative_regulation (abrogated) of Gene_expression (production) of LCF in mononuclear cells associated with opioid
5) Confidence 0.39 Published 1985 Journal J. Immunol. Section Abstract Doc Link 3156934 Disease Relevance 0 Pain Relevance 0.95
The suppression of LCF production mediated by opioid peptides in mononuclear supernatants was abrogated by depletion of glass-adherent mononuclear cells before culturing with opioids and Con A.
Negative_regulation (suppression) of Gene_expression (production) of LCF in mononuclear cells associated with opioid
6) Confidence 0.39 Published 1985 Journal J. Immunol. Section Abstract Doc Link 3156934 Disease Relevance 0 Pain Relevance 0.94
Additional experiments showed that exogenous prostaglandin E2 (PGE2) suppressed Con A-stimulated LCF production when added at concentrations ranging from 10(-6) to 10(-8) M.
Negative_regulation (suppressed) of Gene_expression (production) of LCF in PGE2
7) Confidence 0.34 Published 1985 Journal J. Immunol. Section Abstract Doc Link 3156934 Disease Relevance 0 Pain Relevance 0.85
Other studies suggested that the mechanism of opioid peptide-mediated suppression of LCF production was due to an enhanced sensitivity of mononuclear cells to the inhibitory action of PGE2.
Negative_regulation (suppression) of Gene_expression (production) of LCF in mononuclear cells associated with opioid
8) Confidence 0.34 Published 1985 Journal J. Immunol. Section Abstract Doc Link 3156934 Disease Relevance 0 Pain Relevance 0.78
The inhibitory effect of opioid peptides on LCF production was prevented by the addition of indomethacin to cell cultures.
Negative_regulation (prevented) of Gene_expression (production) of LCF associated with opioid
9) Confidence 0.34 Published 1985 Journal J. Immunol. Section Abstract Doc Link 3156934 Disease Relevance 0 Pain Relevance 0.92
The inhibitory effect of opioid peptides on LCF production was prevented by the addition of indomethacin to cell cultures.
Negative_regulation (effect) of Gene_expression (production) of LCF associated with opioid
10) Confidence 0.34 Published 1985 Journal J. Immunol. Section Abstract Doc Link 3156934 Disease Relevance 0 Pain Relevance 0.98

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