INT354622

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.38
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CTSB, PRDX5) cytoplasm (CTSB, PRDX5) peroxisome (PRDX5)
intracellular (CTSB) extracellular space (CTSB) peptidase activity (CTSB)
CTSB (Homo sapiens)
PRDX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 3 47.68 Quite Low
cINOD 10 5.00 Very Low Very Low Very Low
aspirin 6 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 3 74.64 Quite High
Cancer 30 71.00 Quite High
Carcinoma 1 56.44 Quite High
Apoptosis 11 5.00 Very Low Very Low Very Low
Breast Cancer 7 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Bacterial Respiratory Disease 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Reprotox - General 1 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was shown by mass spectrometry that RAPTA compounds form adducts with proteins(130) and that the reactivity of RAPTA-C and cisplatin in the presence of proteins was much different.(131) To get more insight, Messori et al. studied the inhibition activity of a series of RAPTA compounds to two proteins, i.e., cathepsin B (Cat B) and thioredoxin reductase (TrxR), which are possible targets for anticancer metallodrugs.(132) They found that all tested Ru compounds were inhibitors of Cat B while none of them, with the exception of RAPTA-C, was inhibiting TrxR.
cathepsin B Spec (possible) Regulation (targets) of thioredoxin reductase
1) Confidence 0.00 Published 2010 Journal Journal of Medicinal Chemistry Section Body Doc Link PMC3018145 Disease Relevance 0.38 Pain Relevance 0

General Comments

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