INT35465

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Context Info
Confidence 0.57
First Reported 1980
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.84
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pfkm) kinase activity (Pfkm) cytoplasm (Pfkm)
Anatomy Link Frequency
brain 2
myocardium 1
microglia 1
Pfkm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 8 99.98 Very High Very High Very High
Pain 3 99.60 Very High Very High Very High
narcan 8 98.96 Very High Very High Very High
ischemia 12 98.16 Very High Very High Very High
Potency 1 97.20 Very High Very High Very High
Opioid 8 93.64 High High
induced neuropathy 1 91.68 High High
cerebral cortex 1 89.52 High High
anesthesia 2 87.60 High High
Sciatic nerve 1 87.44 High High
Disease Link Frequency Relevance Heat
Stress 8 99.74 Very High Very High Very High
Necrosis 6 98.92 Very High Very High Very High
Cv Unclassified Under Development 8 98.16 Very High Very High Very High
Drug Induced Neurotoxicity 2 97.80 Very High Very High Very High
Hypoxia 6 97.68 Very High Very High Very High
Diabetes Mellitus 46 97.58 Very High Very High Very High
Aging 3 92.60 High High
Disease 8 92.24 High High
Neuropathic Pain 2 91.68 High High
Congenital Anomalies 1 90.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine inhibited phosphofructokinase (PFK) and stimulated phosphohexose isomerase (PHI) activities.
Negative_regulation (inhibited) of PFK associated with morphine
1) Confidence 0.57 Published 1980 Journal J. Endocrinol. Section Abstract Doc Link 6447740 Disease Relevance 0 Pain Relevance 0.84
Morphine inhibited phosphofructokinase (PFK) and stimulated phosphohexose isomerase (PHI) activities.
Negative_regulation (inhibited) of phosphofructokinase associated with morphine
2) Confidence 0.50 Published 1980 Journal J. Endocrinol. Section Abstract Doc Link 6447740 Disease Relevance 0 Pain Relevance 0.84
Phosphofructokinase was also inhibited by some of the test compounds, independently of their neurotoxicity.
Negative_regulation (inhibited) of Phosphofructokinase associated with drug induced neurotoxicity
3) Confidence 0.46 Published 1985 Journal Toxicol. Lett. Section Abstract Doc Link 3161219 Disease Relevance 0.29 Pain Relevance 0.14
Phosphofructokinase activity was inhibited by methohexital in the recovery period after ischemia or anoxia, respectively. 5.
Negative_regulation (inhibited) of Phosphofructokinase associated with hypoxia and ischemia
4) Confidence 0.42 Published 1982 Journal Arzneimittelforschung Section Abstract Doc Link 7202367 Disease Relevance 0.87 Pain Relevance 0.31
In myocardium necrosis developed after emotional-painful stress activity of phosphofructokinase was decreased within 2 days as compared with the animals, myocardial necrosis of which was produces using the routine procedures.
Negative_regulation (decreased) of phosphofructokinase in myocardium associated with stress, pain and necrosis
5) Confidence 0.41 Published 1985 Journal Vopr. Med. Khim. Section Abstract Doc Link 3157268 Disease Relevance 0.79 Pain Relevance 0.19
The results revealed an interlinked significant age-related increase in soluble hexokinase (HK) and a significant decrease in phosphofructokinase (PFK) activity in human autoptic tissue, whereas no significant age-dependent differences could be observed in rat brain.
Negative_regulation (decrease) of phosphofructokinase in brain
6) Confidence 0.19 Published 1980 Journal Aktuelle Gerontol Section Abstract Doc Link 6106427 Disease Relevance 0.25 Pain Relevance 0.12
An earlier work [31] showed that alloxan-induced diabetes of 4-day duration produced metabolite changes in the brain, compatible with severe reduction of cerebral metabolism and reduced phosphofructokinase activity.
Negative_regulation (reduced) of phosphofructokinase in brain associated with diabetes mellitus
7) Confidence 0.12 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC443509 Disease Relevance 1.24 Pain Relevance 0.07
The ability of resveratrol to reduce PGE2 production comes from the modulation of multiple events in the COX/PGE2 pathway: 1) resveratrol is a potent inactivator of the peroxidase reaction of COX-1 [43], and thus is considered a relatively selective inhibitor of this isozyme; 2) resveratrol significantly diminished LPS-induced expression of mPGES-1 (Figs. 3 and 4), the most important terminal synthase responsible for PGE2 synthesis in activated microglia [42]; and 3) production of 8-iso-PGF2?
Negative_regulation (inhibitor) of isozyme in microglia
8) Confidence 0.01 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0.40 Pain Relevance 0.09

General Comments

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