INT354668

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.54
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Bfar) molecular_function (Bfar)
Bfar (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 3 78.48 Quite High
Glutamate 3 73.44 Quite High
Pain 3 58.72 Quite High
Multiple sclerosis 3 56.52 Quite High
ischemia 3 55.40 Quite High
Central nervous system 3 41.44 Quite Low
ASIC 33 38.20 Quite Low
imagery 9 5.00 Very Low Very Low Very Low
Dopamine 6 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Male Infertility 3 90.24 High High
Disease 12 61.60 Quite High
Pain 3 58.72 Quite High
Convulsion 3 58.12 Quite High
Demyelinating Disease 3 56.52 Quite High
Cv Unclassified Under Development 3 55.40 Quite High
Neurological Disease 3 54.64 Quite High
Anxiety Disorder 3 51.04 Quite High
Acidosis 12 20.96 Low Low
Toxicity 18 19.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PICK1-regulated surface expression of ASIC1a is dependent on the lipid binding of PICK1's BAR domain
BAR Binding (binding) of
1) Confidence 0.06 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.04
The BAR domain of PICK1 binds to lipids and this lipid binding regulates surface expression of AMPA receptors [36].
BAR Binding (binds) of
2) Confidence 0.04 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.04
In addition to the PDZ domain, the middle portion of PICK1 contains a BAR (Bin/amphiphysin/Rvs) domain [35], which directly binds to lipids, mainly phosphoinositols [36].
BAR Binding (binds) of
3) Confidence 0.04 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.54 Pain Relevance 0.15

General Comments

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