INT35467

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 1983
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 37
Total Number 39
Disease Relevance 9.56
Pain Relevance 12.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (DIO2) plasma membrane (DIO2) cellular nitrogen compound metabolic process (DIO2)
Anatomy Link Frequency
spinal cord 3
dorsal horns 3
corticotroph 3
fingers 2
striatum 2
DIO2 (Homo sapiens)
Pain Link Frequency Relevance Heat
dopamine receptor 65 100.00 Very High Very High Very High
antagonist 149 99.96 Very High Very High Very High
Dorsal horn 50 99.68 Very High Very High Very High
Dopamine 1316 99.62 Very High Very High Very High
agonist 304 99.58 Very High Very High Very High
Spinal cord 441 99.56 Very High Very High Very High
withdrawal 36 99.44 Very High Very High Very High
chemokine 45 99.30 Very High Very High Very High
Anterior cingulate 2 98.12 Very High Very High Very High
noradrenaline 35 97.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 229 100.00 Very High Very High Very High
Necrosis 20 100.00 Very High Very High Very High
Prolactinoma 144 99.98 Very High Very High Very High
Acth-secreting Pituitary Adenoma 42 99.98 Very High Very High Very High
Adenoma 48 99.78 Very High Very High Very High
Syndrome 96 96.92 Very High Very High Very High
Dystonia 37 96.56 Very High Very High Very High
Disease 332 95.04 Very High Very High Very High
INFLAMMATION 23 94.32 High High
Metabolic Disorder 1 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar effects were produced by the selective D-2 antagonists, sulpiride and metoclopramide, which had no effect on hyperpolarizations evoked by norepinephrine.
Gene_expression (produced) of D-2 associated with antagonist
1) Confidence 0.65 Published 1985 Journal Brain Res. Section Abstract Doc Link 3157424 Disease Relevance 0 Pain Relevance 0.70
The possibility of a defect in d-2-hydroxyglutarate dehydrogenation prompted us to employ E. coli d-2-hydroxyacid dehydrogenase cDNA to search the human expressed sequence tags database.
Gene_expression (expressed) of d-2
2) Confidence 0.65 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10679197 Disease Relevance 0.09 Pain Relevance 0.09
Group D 2 1,000 mL of 10% of glucose in water, 40 units of fast acting insulin in the same rate as Group B.
Gene_expression (acting) of D 2
3) Confidence 0.65 Published 2008 Journal Arch Cardiol Mex Section Abstract Doc Link 18754408 Disease Relevance 0.23 Pain Relevance 0.09
There was a significantly higher peak pain rating after D2 compared to C2 during MVBF or MVJO (P<0.022), whereas no significant difference in peak pain ratings was found between A2 and B2 (P>0.084).
Neg (no) Gene_expression (was) of D2
4) Confidence 0.52 Published 2010 Journal Clin Neurophysiol Section Body Doc Link 20153690 Disease Relevance 0 Pain Relevance 0
Without D2 activation, acceleration of contraction is blocked, movement acceleration cannot occur, and stepping fails.
Gene_expression (activation) of D2
5) Confidence 0.35 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0.12 Pain Relevance 0.20
Urinary concentrations of tumor necrosis factor, prostaglandins E2, D2 and F2 alpha, and thromboxane B2 were not different among either patient groups or controls.
Gene_expression (concentrations) of D2 associated with necrosis and cancer
6) Confidence 0.32 Published 1994 Journal J. Urol. Section Abstract Doc Link 8015071 Disease Relevance 1.36 Pain Relevance 0.42
As dopamine release is acutely impaired, synaptic concentration cannot achieve a level necessary for micromolar D2 activation.
Gene_expression (activation) of D2 associated with dopamine
7) Confidence 0.31 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0.12 Pain Relevance 0.21
In the present study, the density of striatal DA terminals and DA receptors and the expression of D-1, D-2, and D-3 receptors, preproenkephalin (PPE-A), preprotachykinin (PPT), and nitric oxide synthase (NOS) mRNAs in the striatum and nucleus accumbens and nigral TH mRNA expression were examined.
Gene_expression (expression) of D-2 in nucleus accumbens associated with nucleus accumbens and dopamine
8) Confidence 0.29 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.36 Pain Relevance 0.59
It is well accepted that, in humans, most circulating T3 is derived from extrathyroidal deiodination of T4 via D2 [3]; thus, it makes sense to hypothesize that defects in D2 expression/activity could interfere with the efficacy of L-T4 monotherapy.
Gene_expression (expression) of D2
9) Confidence 0.27 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2950057 Disease Relevance 0.72 Pain Relevance 0.10
Role of dopamine agonists in proliferation of D2 receptors
Gene_expression (receptors) of D2 associated with dopamine and agonist
10) Confidence 0.22 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0.16 Pain Relevance 0.60
Because the D2 reductions are associated with decreased activity in the anterior cingulate gyrus and in the orbitofrontal cortex they postulate that this is one of the mechanisms by which DA disruption leads to compulsive drug administration and the lack of control over drug intake in the drug-addicted individual.
Gene_expression (reductions) of D2 in cortex associated with dopamine and anterior cingulate
11) Confidence 0.19 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0.32 Pain Relevance 0.58
Venlafaxine probably inhibits serotonin uptake only in low doses, whereas both serotonin and noradrenaline uptake are inhibited following high doses.115 The drug does not possess significant affinity for 5HT1A, 5HT2A, D2, muscarinic, or ?
Gene_expression (5HT2A) of D2 associated with noradrenaline and serotonin
12) Confidence 0.18 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 0.36 Pain Relevance 0.42
In the dopamine receptor network, many ligands are preferably predicted for dopamine receptor D2, and small number of ligands like perphenazine hydrochloride (D04965) is common among all dopamine receptors (D1, D2 and D3).
Gene_expression (predicted) of D2 associated with dopamine receptor
13) Confidence 0.17 Published 2008 Journal Bioinformatics Section Body Doc Link PMC2718640 Disease Relevance 0 Pain Relevance 0.53
Repeated measures ANOVA for factors GROUP and SESSION revealed no significant interaction for d1 of the right hand (F(3,60)= 0.060, p = 0.981) and left d2 (F(3,60) =0.387, p = 0.763), but for fingers d2 (F(3,60) =7.519, p ?
Gene_expression (left) of d2 in fingers
14) Confidence 0.14 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682400 Disease Relevance 0 Pain Relevance 0
Repeated measures ANOVA for factors GROUP and SESSION revealed no significant interaction for d1 of the right hand (F(3,60)= 0.060, p = 0.981) and left d2 (F(3,60) =0.387, p = 0.763), but for fingers d2 (F(3,60) =7.519, p ?
Gene_expression (=7.519) of d2 in fingers
15) Confidence 0.14 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682400 Disease Relevance 0 Pain Relevance 0
By contrast, we show that the D2 and D3 receptor subtypes are expressed in the lumbar spinal cord as in the rat where the D2 [58], [59] and D3 [60] receptor subtypes are highly expressed.
Gene_expression (expressed) of D2 in spinal cord associated with spinal cord
16) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0.15 Pain Relevance 0.80
Overall, D2, D3 and D5 receptor subtypes were expressed in the lumbar spinal cord sections.
Gene_expression (expressed) of D2 in spinal cord associated with spinal cord
17) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0.11 Pain Relevance 0.49
As D2 receptors are more highly expressed in the dorsal horn, their stimulation might contribute to modulating the somesthetic processes and spinal reflexes [13].
Gene_expression (expressed) of D2 in dorsal horn associated with dorsal horn
18) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0.12 Pain Relevance 0.64
The detection of D2 labeling in spinal cord sections showed that D2 receptors were intensely expressed in the dorsal horns mainly within the laminae I to VI, as illustrated in Figure 2C.
Gene_expression (expressed) of D2 in dorsal horns associated with spinal cord
19) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0 Pain Relevance 0.36
Levels in D2 were higher than S2 or controls for MCP-1 and M-CSF.
Gene_expression (Levels) of D2
20) Confidence 0.12 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2950153 Disease Relevance 0.07 Pain Relevance 0.34

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox