INT354671

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.71
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Bfar) molecular_function (Bfar)
Bfar (Mus musculus)
Pain Link Frequency Relevance Heat
ASIC 22 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 16 93.28 High High
Acidosis 8 77.60 Quite High
Toxicity 12 75.84 Quite High
Apoptosis 2 54.72 Quite High
Brain Injury 2 19.20 Low Low
Disease 8 17.20 Low Low
Pain 2 5.00 Very Low Very Low Very Low
Neurological Disease 2 5.00 Very Low Very Low Very Low
Demyelinating Disease 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both the PDZ and BAR domains are required for PICK1's effect on surface expression of ASIC1a, we therefore asked if the PDZ and BAR domain mutants abolish the potentiation effect of PICK1 on acid-induced cell death.
Positive_regulation (required) of BAR associated with death
1) Confidence 0.07 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.45 Pain Relevance 0
These results suggest that the BAR domain is not required for PICK1 to interact with ASIC1a but is necessary for it to cluster ASIC1a.


Neg (not) Positive_regulation (required) of BAR
2) Confidence 0.07 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.26 Pain Relevance 0

General Comments

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