INT354680

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.51
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pick1) protein targeting (Pick1) Golgi apparatus (Pick1)
ATPase activity (Pick1) plasma membrane (Pick1) enzyme binding (Pick1)
Pick1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 3 55.96 Quite High
ASIC 33 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
Dopamine 6 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
Multiple sclerosis 3 5.00 Very Low Very Low Very Low
Glutamate receptor 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acidosis 12 89.84 High High
Toxicity 18 88.08 High High
Apoptosis 3 66.96 Quite High
Death 24 65.76 Quite High
Disease 12 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Neurological Disease 3 5.00 Very Low Very Low Very Low
Demyelinating Disease 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Male Infertility 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, PICK1 2K-E had no effect on ASIC1a:PICK1 interaction (Figure 3).
Neg (no) Regulation (effect) of PICK1 Neg (no) Binding (interaction) of
1) Confidence 0.39 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.14 Pain Relevance 0
PICK1 regulates ASIC1a-mediated acidotoxicity in a lipid-binding dependent manner
Regulation (dependent) of PICK1 Binding (binding) of
2) Confidence 0.39 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.37 Pain Relevance 0
Next, we asked whether lipid binding of PICK1 affects ASIC1a subcellular localization.
Spec (whether) Regulation (affects) of PICK1 Spec (whether) Binding (binding) of
3) Confidence 0.39 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.03

General Comments

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