INT354685

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Context Info
Confidence 0.66
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.25
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ASIC1) transport (ASIC1) plasma membrane (ASIC1)
Anatomy Link Frequency
synapses 1
ASIC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 98.40 Very High Very High Very High
Multiple sclerosis 6 96.20 Very High Very High Very High
ischemia 6 95.08 Very High Very High Very High
ASIC 66 87.04 High High
Dopamine 12 86.80 High High
Central nervous system 6 81.12 Quite High
Glutamate receptor 6 66.72 Quite High
Glutamate 6 54.96 Quite High
Kinase C 6 43.76 Quite Low
imagery 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 24 99.84 Very High Very High Very High
Pain 6 98.40 Very High Very High Very High
Convulsion 6 97.80 Very High Very High Very High
Demyelinating Disease 6 96.20 Very High Very High Very High
Cv Unclassified Under Development 6 95.08 Very High Very High Very High
Neurological Disease 6 94.32 High High
Anxiety Disorder 6 90.72 High High
Toxicity 36 77.40 Quite High
Acidosis 24 73.76 Quite High
Death 48 72.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, and similar to our earlier studies on AMPA receptors [36], the effect of PICK1 on ASIC1a localization and surface also requires the lipid binding of PICK1.
Localization (localization) of ASIC1a
1) Confidence 0.66 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.48 Pain Relevance 0.08
This result indicates that PICK1 requires its lipid binding ability to regulate the subcellular localization of ASIC1a.
Localization (localization) of ASIC1a
2) Confidence 0.66 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0
Next, we asked whether lipid binding of PICK1 affects ASIC1a subcellular localization.
Localization (localization) of ASIC1a
3) Confidence 0.66 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.03
Our results here may provide one possible mechanism for regulating ASIC1a targeting to synapses.
Localization (targeting) of ASIC1a in synapses
4) Confidence 0.62 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.11
It will be interesting to address the question if manipulating PICK1 changes ASIC1a synaptic localization in the future.
Localization (localization) of ASIC1a
5) Confidence 0.62 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.11
These studies demonstrate the importance of ASIC1a in diseases.
Localization (importance) of ASIC1a associated with disease
6) Confidence 0.62 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.77 Pain Relevance 0.44

General Comments

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