INT354687

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Context Info
Confidence 0.51
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 1.00
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ASIC1) transport (ASIC1) plasma membrane (ASIC1)
ASIC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 7 90.76 High High
Multiple sclerosis 7 88.56 High High
Glutamate 7 88.32 High High
ischemia 7 87.44 High High
Glutamate receptor 7 82.72 Quite High
Central nervous system 7 73.48 Quite High
ASIC 77 70.24 Quite High
imagery 21 5.00 Very Low Very Low Very Low
Dopamine 14 5.00 Very Low Very Low Very Low
nMDA receptor 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 28 93.64 High High
Pain 7 90.76 High High
Convulsion 7 90.16 High High
Demyelinating Disease 7 88.56 High High
Cv Unclassified Under Development 7 87.44 High High
Acidosis 28 86.88 High High
Neurological Disease 7 86.68 High High
Toxicity 42 85.12 High High
Anxiety Disorder 7 83.08 Quite High
Male Infertility 7 59.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PICK1-regulated surface expression of ASIC1a is dependent on the lipid binding of PICK1's BAR domain
Regulation (regulated) of Gene_expression (expression) of ASIC1a
1) Confidence 0.51 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.03
This result indicates that lipid binding is required for PICK1-regulated surface expression of ASIC1a.
Regulation (regulated) of Gene_expression (expression) of ASIC1a
2) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.04
However, molecular mechanism regulating ASIC1a trafficking is not well understood.
Regulation (regulating) of Gene_expression (trafficking) of ASIC1a
3) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.77 Pain Relevance 0.41
As expected, PICK1 KD-AA had no effect on ASIC1a surface levels (surface ASIC1a ratio with PICK1 KA-AA: 5.42% ± 1.6%, p < 0.05 comparing to ASIC1a + PICK1, not significant comparing to ASIC1a alone or ASIC1a + PICK1 2K-E, n = 4, Figure 1C).
Neg (no) Regulation (effect) of Gene_expression (ratio) of ASIC1a
4) Confidence 0.32 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.04
As expected, PICK1 KD-AA had no effect on ASIC1a surface levels (surface ASIC1a ratio with PICK1 KA-AA: 5.42% ± 1.6%, p < 0.05 comparing to ASIC1a + PICK1, not significant comparing to ASIC1a alone or ASIC1a + PICK1 2K-E, n = 4, Figure 1C).
Neg (no) Regulation (effect) of Gene_expression (ratio) of ASIC1a
5) Confidence 0.32 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.04
These results indicate that both the PDZ and BAR domains are required for PICK1 to regulate ASIC1a surface expression.


Regulation (regulate) of Gene_expression (expression) of ASIC1a
6) Confidence 0.22 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.03
Given that PICK1 regulates trafficking of several membrane proteins, and that PICK1 directly interacts with ASIC1, we hypothesize here that PDZ and BAR domains of PICK1 cooperatively regulate ASIC1a surface expression.
Regulation (regulate) of Gene_expression (expression) of ASIC1a
7) Confidence 0.22 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.23 Pain Relevance 0

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