INT354688

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Context Info
Confidence 0.67
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.23
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ASIC1) transport (ASIC1) plasma membrane (ASIC1)
ASIC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 2 97.92 Very High Very High Very High
Glutamate 2 57.96 Quite High
ASIC 22 55.24 Quite High
imagery 6 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 16 88.96 High High
Acidosis 8 88.20 High High
Toxicity 12 51.40 Quite High
Disease 8 38.88 Quite Low
Brain Injury 2 38.08 Quite Low
Pain 2 5.00 Very Low Very Low Very Low
Neurological Disease 2 5.00 Very Low Very Low Very Low
Demyelinating Disease 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, protein kinase A was reported to phosphorylate ASIC1a and inhibit its interaction with PICK1 [41], while protein kinase C was reported to enhance ASIC2a-mediated current via PICK1 [40].
Phosphorylation (phosphorylate) of ASIC1a associated with kinase c
1) Confidence 0.67 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.23 Pain Relevance 0.13
Lipid binding is required for PICK1-induced clustering of ASIC1a
Phosphorylation (clustering) of ASIC1a
2) Confidence 0.67 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.03

General Comments

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