INT354693

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Context Info
Confidence 0.51
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ASIC1) transport (ASIC1) plasma membrane (ASIC1)
Anatomy Link Frequency
synapses 2
ASIC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ASIC 33 87.48 High High
Dopamine 6 77.28 Quite High
Glutamate 3 55.28 Quite High
Kinase C 3 38.28 Quite Low
imagery 9 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
Multiple sclerosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acidosis 12 33.84 Quite Low
Targeted Disruption 3 33.12 Quite Low
Toxicity 18 32.08 Quite Low
Death 24 23.72 Low Low
Apoptosis 3 10.96 Low Low
Disease 12 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Neurological Disease 3 5.00 Very Low Very Low Very Low
Demyelinating Disease 3 5.00 Very Low Very Low Very Low
Male Infertility 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This result indicates that PICK1 requires its lipid binding ability to regulate the subcellular localization of ASIC1a.
Regulation (regulate) of Localization (localization) of ASIC1a
1) Confidence 0.51 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0
Next, we asked whether lipid binding of PICK1 affects ASIC1a subcellular localization.
Spec (whether) Regulation (affects) of Localization (localization) of ASIC1a
2) Confidence 0.51 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.03
Our results here may provide one possible mechanism for regulating ASIC1a targeting to synapses.
Spec (possible) Regulation (regulating) of Localization (targeting) of ASIC1a in synapses
3) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.11

General Comments

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