INT354699

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.22
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn2, Pick1) mitochondrion (Pick1) transport (Accn2)
protein targeting (Pick1) Golgi apparatus (Pick1) ATPase activity (Pick1)
Accn2 (Mus musculus)
Pick1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 1 48.72 Quite Low
Pain 1 28.96 Quite Low
Multiple sclerosis 1 26.76 Quite Low
ischemia 1 25.64 Quite Low
Central nervous system 1 11.68 Low Low
ASIC 11 8.44 Low Low
imagery 3 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
nMDA receptor 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acidosis 4 78.56 Quite High
Toxicity 6 76.80 Quite High
Male Infertility 1 60.48 Quite High
Disease 4 31.84 Quite Low
Pain 1 28.96 Quite Low
Convulsion 1 28.36 Quite Low
Demyelinating Disease 1 26.76 Quite Low
Cv Unclassified Under Development 1 25.64 Quite Low
Neurological Disease 1 24.88 Low Low
Anxiety Disorder 1 21.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given that PICK1 regulates trafficking of several membrane proteins, and that PICK1 directly interacts with ASIC1, we hypothesize here that PDZ and BAR domains of PICK1 cooperatively regulate ASIC1a surface expression.
ASIC1 Binding (interacts) of PICK1
1) Confidence 0.07 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.22 Pain Relevance 0

General Comments

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