INT354700

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.90
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pick1) endoplasmic reticulum (Bfar) Golgi apparatus (Pick1)
enzyme binding (Pick1) protein complex (Pick1) cytoplasm (Pick1)
Pick1 (Mus musculus)
Bfar (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 3 79.16 Quite High
Pain 3 59.40 Quite High
Dopamine 6 59.00 Quite High
Multiple sclerosis 3 57.20 Quite High
ischemia 3 56.08 Quite High
Central nervous system 3 42.12 Quite Low
ASIC 33 38.88 Quite Low
imagery 9 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Male Infertility 3 90.92 High High
Targeted Disruption 3 81.08 Quite High
Acidosis 12 79.36 Quite High
Toxicity 18 77.60 Quite High
Disease 12 62.28 Quite High
Pain 3 59.40 Quite High
Convulsion 3 58.80 Quite High
Demyelinating Disease 3 57.20 Quite High
Apoptosis 3 56.48 Quite High
Cv Unclassified Under Development 3 56.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the BAR domain is not required for PICK1 to interact with ASIC1a but is necessary for it to cluster ASIC1a.


PICK1 Binding (interact) of BAR
1) Confidence 0.05 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.27 Pain Relevance 0
While the detailed mechanisms need more clarification, these findings suggest that PICK1 is a common protein trafficking regulator that couples membrane proteins to trafficking machinery via its unique combination of the PDZ domain and BAR domain.


PICK1 Binding (combination) of BAR
2) Confidence 0.05 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.08 Pain Relevance 0.03
In addition to the PDZ domain, the middle portion of PICK1 contains a BAR (Bin/amphiphysin/Rvs) domain [35], which directly binds to lipids, mainly phosphoinositols [36].
PICK1 Binding (binds) of BAR
3) Confidence 0.04 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.55 Pain Relevance 0.16

General Comments

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