INT354710

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Context Info
Confidence 0.37
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.12
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pick1, ASIC1) transport (ASIC1) mitochondrion (Pick1)
Golgi apparatus (Pick1) enzyme binding (Pick1) protein complex (Pick1)
Pick1 (Mus musculus)
ASIC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ASIC 66 94.88 High High
Kinase C 6 68.64 Quite High
Glutamate 6 62.80 Quite High
Glutamate receptor 6 34.96 Quite Low
Pain 6 15.20 Low Low
Multiple sclerosis 6 13.00 Low Low
ischemia 6 11.88 Low Low
imagery 18 5.00 Very Low Very Low Very Low
Dopamine 12 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 36 99.56 Very High Very High Very High
Acidosis 24 99.32 Very High Very High Very High
Death 48 98.44 Very High Very High Very High
Disease 24 86.72 High High
Brain Injury 6 51.76 Quite High
Male Infertility 6 46.72 Quite Low
Pain 6 15.20 Low Low
Convulsion 6 14.60 Low Low
Demyelinating Disease 6 13.00 Low Low
Cv Unclassified Under Development 6 11.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that PICK1 regulates the glycosylation and/or maturation of ASIC1a.


PICK1 Regulation (regulates) of ASIC1a
1) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.03
These findings provide a mechanistic understanding of PICK1's role on ASIC1a trafficking and acidosis-induced cell death.
PICK1 Regulation (role) of ASIC1a associated with acidosis and death
2) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.43 Pain Relevance 0.10
PICK1 regulates the trafficking of ASIC1a and acidotoxicity in a BAR domain lipid binding-dependent manner

Background

PICK1 Regulation (regulates) of ASIC1a
3) Confidence 0.22 Published 2010 Journal Mol Brain Section Title Doc Link PMC3018362 Disease Relevance 0.18 Pain Relevance 0.05
PICK1 regulates surface levels of ASIC1a
PICK1 Regulation (regulates) of ASIC1a
4) Confidence 0.22 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.20 Pain Relevance 0
To examine if PICK1 regulates the level of ASIC1a at cell surface, we performed cell surface protein biotinylation assay to measure the surface level of human ASIC1a.
PICK1 Spec (examine) Regulation (regulates) of ASIC1a
5) Confidence 0.22 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.18 Pain Relevance 0
Taken together, our results indicate that PICK1 regulates trafficking and function of ASIC1a in a lipid binding-dependent manner.



PICK1 Regulation (regulates) of ASIC1a
6) Confidence 0.22 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC3018362 Disease Relevance 0.14 Pain Relevance 0.03

General Comments

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