INT354712

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.74
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pick1, ASIC1) transport (ASIC1) mitochondrion (Pick1)
Golgi apparatus (Pick1) enzyme binding (Pick1) protein complex (Pick1)
Pick1 (Mus musculus)
ASIC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ASIC 33 79.20 Quite High
Glutamate 3 67.60 Quite High
Glutamate receptor 3 5.44 Low Low
imagery 9 5.00 Very Low Very Low Very Low
Dopamine 6 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
Multiple sclerosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 12 98.56 Very High Very High Very High
Brain Injury 3 97.76 Very High Very High Very High
Toxicity 18 95.88 Very High Very High Very High
Death 24 76.28 Quite High
Acidosis 12 69.16 Quite High
Male Infertility 3 17.20 Low Low
Apoptosis 3 7.64 Low Low
Pain 3 5.00 Very Low Very Low Very Low
Neurological Disease 3 5.00 Very Low Very Low Very Low
Demyelinating Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PICK1-regulated surface expression of ASIC1a is dependent on the lipid binding of PICK1's BAR domain
PICK1 Positive_regulation (dependent) of Gene_expression (expression) of ASIC1a
1) Confidence 0.39 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.03
As shown in Figure 1B, PICK1 significantly increases surface expression of ASIC1a.
PICK1 Positive_regulation (increases) of Gene_expression (expression) of ASIC1a
2) Confidence 0.39 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.14 Pain Relevance 0
Our result that PICK1 increases surface levels of ASIC1a and ASIC1a-mediated acidotoxicity provides an interesting way to regulate ASIC1a in acid-induced cell toxicity.
PICK1 Positive_regulation (increases) of Gene_expression (levels) of ASIC1a associated with toxicity
3) Confidence 0.39 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.60 Pain Relevance 0.08

General Comments

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