INT354720

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.61
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ASIC1) transport (ASIC1) endoplasmic reticulum (Bfar)
plasma membrane (ASIC1) molecular_function (Bfar)
ASIC1 (Homo sapiens)
Bfar (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 3 10.48 Low Low
ASIC 33 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
Dopamine 6 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
Multiple sclerosis 3 5.00 Very Low Very Low Very Low
Glutamate receptor 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acidosis 12 83.68 Quite High
Toxicity 18 81.92 Quite High
Apoptosis 3 60.80 Quite High
Death 24 59.60 Quite High
Disease 12 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Neurological Disease 3 5.00 Very Low Very Low Very Low
Demyelinating Disease 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Male Infertility 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the BAR domain is not required for PICK1 to interact with ASIC1a but is necessary for it to cluster ASIC1a.


ASIC1a Binding (necessary) of BAR
1) Confidence 0.05 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.34 Pain Relevance 0
These results suggest that the BAR domain is not required for PICK1 to interact with ASIC1a but is necessary for it to cluster ASIC1a.


ASIC1a Binding (interact) of BAR
2) Confidence 0.05 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.27 Pain Relevance 0
To answer the question whether mutating the BAR domain of PICK1 interferes with its interaction with ASIC1a, we performed co-immunoprecipitation analysis.
ASIC1a Binding (interaction) of BAR
3) Confidence 0.04 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0

General Comments

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