INT354742

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.74
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATM) signal transduction (ATM) cell death (ATM)
cytoplasmic membrane-bounded vesicle (ATM) nucleus (ATM) DNA binding (ATM)
ATM (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 16 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Pyramidal cell 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Telangiectasia 2 90.20 High High
Ataxia 6 89.60 High High
Dementia 8 87.72 High High
Neuroblastoma 2 87.04 High High
Disease 224 86.72 High High
Death 10 83.88 Quite High
Cognitive Disorder 16 81.28 Quite High
Stress 14 60.64 Quite High
Alzheimer's Dementia 2 59.04 Quite High
Targeted Disruption 4 43.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether the 53BP1 response was reflective of a broader ATM-dependent response to DNA damage, we examined ATM auto-phosphorylation with a phospho-ser1981 specific antibody (Figure 2C, D).
Phosphorylation (phosphorylation) of ATM
1) Confidence 0.50 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3018387 Disease Relevance 0.74 Pain Relevance 0
To detect DNA damage, we used a rabbit polyclonal 53BP1 antibody (ab36823, Abcam); a rabbit polyclonal antibody against phosphorylated Chk2 kinase (on threonine residue 68) - P-Chk2 (ab38461, Abcam) and a rabbit monoclonal antibody against phosphorylated ATM kinase (on serine residue 1981) - P-ATM (ab81292, Abcam).
Phosphorylation (phosphorylated) of ATM
2) Confidence 0.44 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3018387 Disease Relevance 1.01 Pain Relevance 0

General Comments

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