INT354747

Context Info Confidence 0.08 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.91 Pain Relevance 0.10

plasma membrane (TSHR) cell-cell signaling (TSHR) signal transducer activity (TSHR)

Anatomy Link Frequency blood 1 TSHR (Homo sapiens)

Pain Link Frequency Relevance Heat Somatostatin 1 99.92 Serotonin 1 99.64 Pain 1 5.00 Neuropeptide 1 5.00

Disease Link Frequency Relevance Heat Malignant Neoplastic Disease 3 92.72 Cancer 20 90.24 Prostate Cancer 35 88.28 Disease 10 83.56 Carcinoma 1 40.52 Death 1 38.00 Apoptosis 4 5.00 Metastasis 3 5.00 Aggression 2 5.00 Pain 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

NE cells produce specific proteins, such as neuron specific enolase (NSE), chromograninA (CgA), bombesin, serotonin, somatostatin, a thyroid-stimulating-like peptide, parathyroid hormone-related peptides, and calcitonin which are secreted into the blood stream.

Localization (secreted) of thyroid-stimulating-like peptide in blood associated with somatostatin and serotonin

1) Confidence 0.08 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3018395 Disease Relevance 0.91 Pain Relevance 0.10

General Comments

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