INT354753

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Context Info
Confidence 0.14
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.98
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ren, Agt) extracellular region (Ren, Agt) peptidase activity (Ren)
aging (Agt) intracellular (Ren) extracellular matrix organization (Agt)
Anatomy Link Frequency
heart 1
kidney 1
Ren (Rattus norvegicus)
Agt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 4 75.16 Quite High
imagery 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 150 96.46 Very High Very High Very High
Sprains And Strains 8 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 2 5.00 Very Low Very Low Very Low
Diabetes Mellitus 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrigued by the potential significance of Ang-(1–12) as an endogenous alternate precursor for the formation of Ang I, a series of studies from our laboratory documented the expression of Ang-(1–12) in the heart and kidney of Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats [3] and showed in the isolated heart of three normotensive (Sprague Dawley, Lewis, and WKY) and two hypertensive (congenic mRen2.Lewis and SHR) rats that cardiac formation of Ang I, Ang II, and angiotensin-(1–7) [Ang-(1–7)] occurred through cleavage of Ang-(1–12) via a non-renin pathway. [4] Additional evidence for a renin independent formation of Ang II from Ang-(1–12) was demonstrated in anephric rats as the fall in circulating Ang I and Ang II was associated with increased cardiac content of Ang-(1–12) and Ang II 48 h post-bilateral nephrectomy. [5]
renin Regulation (formation) of Ang II in heart associated with hypertension
1) Confidence 0.14 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.49 Pain Relevance 0.04
Intrigued by the potential significance of Ang-(1–12) as an endogenous alternate precursor for the formation of Ang I, a series of studies from our laboratory documented the expression of Ang-(1–12) in the heart and kidney of Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats [3] and showed in the isolated heart of three normotensive (Sprague Dawley, Lewis, and WKY) and two hypertensive (congenic mRen2.Lewis and SHR) rats that cardiac formation of Ang I, Ang II, and angiotensin-(1–7) [Ang-(1–7)] occurred through cleavage of Ang-(1–12) via a non-renin pathway. [4] Additional evidence for a renin independent formation of Ang II from Ang-(1–12) was demonstrated in anephric rats as the fall in circulating Ang I and Ang II was associated with increased cardiac content of Ang-(1–12) and Ang II 48 h post-bilateral nephrectomy. [5]
renin Regulation (formation) of Ang II in kidney associated with hypertension
2) Confidence 0.05 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.49 Pain Relevance 0.04

General Comments

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