INT354790

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MMP3, OSM) extracellular region (MMP3, OSM) cell proliferation (OSM)
peptidase activity (MMP3) proteinaceous extracellular matrix (MMP3) nucleus (MMP3)
MMP3 (Homo sapiens)
OSM (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 9 100.00 Very High Very High Very High
Osteoarthritis 40 73.20 Quite High
cytokine 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 1 84.88 Quite High
Frailty 40 73.20 Quite High
Hip Osteoarthritis 1 50.00 Quite Low
Obesity 12 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Chondrosarcoma 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Starvation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DADS is reported to have HDAC inhibitor activity [28] so we measured both the activity of DADS to induce acetylation of histones, and also its ability to repress the IL-1 or IL-1/OSM-induced expression of key MMPs, MMP-1 and -13 (collagen-degrading enzymes) and MMP-3 (an activator of proMMPs) in a model cell line.
MMP-3 Negative_regulation (repress) of Gene_expression (expression) of OSM associated with metalloproteinase
1) Confidence 0.00 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3018463 Disease Relevance 0.27 Pain Relevance 0.31

General Comments

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