INT354814

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Context Info
Confidence 0.29
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.61
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fasl) extracellular space (Fasl) extracellular region (Fasl)
cytoplasmic membrane-bounded vesicle (Fasl) plasma membrane (Fasl) lysosome (Fasl)
Anatomy Link Frequency
neuronal 4
Fasl (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 122 99.38 Very High Very High Very High
dopaminergic neurodegeneration 2 91.60 High High
Inflammation 114 86.00 High High
cytokine 166 84.96 Quite High
chemokine 16 71.00 Quite High
Central nervous system 48 46.40 Quite Low
midbrain 10 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 126 99.84 Very High Very High Very High
Necrosis 9 98.74 Very High Very High Very High
Cancer 13 98.56 Very High Very High Very High
Parkinson's Disease 40 95.52 Very High Very High Very High
Mycobacterial Infection 145 91.64 High High
Disease 218 89.20 High High
Granuloma 5 87.28 High High
INFLAMMATION 150 86.00 High High
Neurodegenerative Disease 34 79.52 Quite High
Adhesions 4 71.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in this study, CD4+ T cell-mediated DA neuronal loss was found to be dependent on the presence of the TNF ligand family member, FasL, and not IFN-?.
Positive_regulation (dependent) of Localization (presence) of FasL in neuronal associated with dopamine
1) Confidence 0.29 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.83 Pain Relevance 0.32
However, in this study, CD4+ T cell-mediated DA neuronal loss was found to be dependent on the presence of the TNF ligand family member, FasL, and not IFN-?.
Positive_regulation (dependent) of Localization (presence) of TNF ligand family member in neuronal associated with dopamine
2) Confidence 0.29 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.82 Pain Relevance 0.32
pathway, such as Tumor necrosis factor alpha-induced protein 2 (TNFAIP2), tumor necrosis factor receptor superfamily member 1b (TNFRSF1B), Fas ligand (FASL) and lymphotoxin (LTB) were all induced at D21 and showed a positive correlation with TNF?
Positive_regulation (induced) of Localization (lymphotoxin) of FASL associated with necrosis, cancer and infection
3) Confidence 0.18 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.96 Pain Relevance 0

General Comments

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