INT354820

Context Info Confidence 0.03 First Reported 2011 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.59 Pain Relevance 0.38

mitochondrion (Creb1, Cpox) oxidoreductase activity (Cpox) nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1) cytoplasm (Cpox)

Creb1 (Mus musculus) Cpox (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 77 99.28 Inflammatory stimuli 2 93.76 Pain 1 81.80 Inflammation 49 79.92 Dopamine 61 68.40 Central nervous system 24 55.80 midbrain 5 5.00 Inflammatory response 4 5.00 Inflammatory mediators 3 5.00 cINOD 3 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 67 93.76 Fever 2 80.20 Infection 8 77.60 Brain Injury 4 76.72 Parkinson's Disease 20 67.60 Disease 108 62.96 Neurodegenerative Disease 17 43.84 Injury 7 37.52 Stress 4 5.40 Death 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

B, cAMP, and CREB) that either enhance or suppress COX-2 transcription [171, 172].

CREB Negative_regulation (suppress) of Transcription (transcription) of COX

1) Confidence 0.03 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.59 Pain Relevance 0.38

General Comments

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