INT35487

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Context Info
Confidence 0.46
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 103
Total Number 104
Disease Relevance 51.24
Pain Relevance 17.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER2) signal transducer activity (PTGER2)
Anatomy Link Frequency
endothelial cells 8
d cells 8
fibroblasts 6
PGE2 6
cartilage 3
PTGER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2027 100.00 Very High Very High Very High
agonist 146 100.00 Very High Very High Very High
Osteoarthritis 657 99.84 Very High Very High Very High
dexamethasone 33 99.60 Very High Very High Very High
bradykinin 122 99.36 Very High Very High Very High
cytokine 2459 99.12 Very High Very High Very High
MU agonist 8 98.70 Very High Very High Very High
Inflammatory mediators 167 98.44 Very High Very High Very High
antagonist 81 98.00 Very High Very High Very High
cINOD 370 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2467 100.00 Very High Very High Very High
Fever 89 100.00 Very High Very High Very High
Herpes Simplex Virus 5950 99.84 Very High Very High Very High
Osteoarthritis 730 99.84 Very High Very High Very High
Infection 2735 99.82 Very High Very High Very High
Injury 187 99.56 Very High Very High Very High
Adhesions 1116 99.44 Very High Very High Very High
Neuroblastoma 13 99.38 Very High Very High Very High
Apoptosis 1012 99.36 Very High Very High Very High
Anaplastic Astrocytoma 5 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The majority of studies of human essential hypertension have documented diminished renal synthesis and, hence, urinary excretion of PGE2.
Localization (excretion) of PGE2 associated with hypertension
1) Confidence 0.46 Published 1985 Journal Adv. Prostaglandin Thromboxane Leukot. Res. Section Abstract Doc Link 3159200 Disease Relevance 0.48 Pain Relevance 0.22
Quantification of PGE2 release
Localization (release) of PGE2
2) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.10 Pain Relevance 0.05
Prostaglandins, especially PGE2, the major PG synthesized by cartilage [5], are spontaneously released by OA cartilages in amounts 50-fold higher than in normal cartilage and 18-fold higher than in normal cartilage stimulated by cytokines [6].
Localization (released) of PGE2 in cartilages associated with osteoarthritis and cytokine
3) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 1.07 Pain Relevance 0.70
We observed an inverse relationship between PGE2 concentration and collagen cleavage activity in OA explant cultures that served as controls by plotting PGE2 concentration versus collagen cleavage in the control OA articular cartilage explants (Figure 1g).
Localization (concentration) of PGE2 in articular cartilage associated with osteoarthritis
4) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.46 Pain Relevance 0.23
This information corroborates our use of PGE1(OH) as a rather specific EP4 receptor subtype agonist and that this receptor subtype is the major pathway for PGE2-induced colonic anion secretion in man, Figure 4.


Localization (secretion) of PGE2 associated with agonist
5) Confidence 0.41 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 0.30 Pain Relevance 0.12
LPS-induced IL-6 and PGE2 release was only slightly inhibited at high doses, whereas LPS-induced release of IL-8 and matrix metalloprotease (MMP)-9 was not affected.
Localization (release) of PGE2
6) Confidence 0.39 Published 2004 Journal Scand. J. Rheumatol. Suppl. Section Abstract Doc Link 15515409 Disease Relevance 0.50 Pain Relevance 0.19
This is accompanied by the upregulation of prostaglandin E synthase-1 (PGES-1) expression and PGE2 release.
Localization (release) of PGE2
7) Confidence 0.39 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.67 Pain Relevance 0.30
This suggests that the IL-1beta induced PGE2 secretion may depend on the availability of arachidonic acid.
Localization (secretion) of PGE2
8) Confidence 0.30 Published 2001 Journal Exp. Gerontol. Section Abstract Doc Link 11250126 Disease Relevance 0.67 Pain Relevance 0.39
Palmitoyl trifluormethyl ketone, an inhibitor of Ca(2+) independent phospholipase A2 (iPLA2) and a less potent inhibitor of cytosolic PLA2, dose-dependently reduced the IL-1beta induced PGE2 secretion.
Localization (secretion) of PGE2
9) Confidence 0.30 Published 2001 Journal Exp. Gerontol. Section Abstract Doc Link 11250126 Disease Relevance 0.68 Pain Relevance 0.41
COX inhibitors indomethacin and BF389, as well as the glucocorticoid dexamethasone (DEX) and pyrrolidinedithiocarbamate, which is an inhibitor of nuclear factor kappaB as well as a potent antioxidant, inhibited IL-1beta induced PGE2 secretion.
Localization (secretion) of PGE2 associated with dexamethasone
10) Confidence 0.30 Published 2001 Journal Exp. Gerontol. Section Abstract Doc Link 11250126 Disease Relevance 0.79 Pain Relevance 0.48
This shows that Gi-protein dependent signals elicit CRC cell proliferation, as corroborated by the ability of PTX to block PGE2 or LPA induced proliferation (Fig. 4B and data not shown).
Localization (proliferation) of PGE2 associated with colon cancer
11) Confidence 0.28 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.16 Pain Relevance 0.09
EP1/3 agonist stimulates and EP2/4 agonists compromise proliferation of Lovo cells
Localization (proliferation) of EP2 associated with agonist
12) Confidence 0.28 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.08 Pain Relevance 0.39
After stimulation with the indicated concentrations of PGE2 for further 120 hours cells were trypsinized, washed once with phosphate-buffered saline (PBS) and resuspended in 100 ?
Localization (concentrations) of PGE2
13) Confidence 0.28 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.06 Pain Relevance 0.03
EP2 and EP4 receptors are coupled with G proteins which activate adenylate cyclase, leading to an increase of intracellular cAMP [41]. cAMP is then able to activate kinases such as protein kinase A (PKA) or PI3K for example, and also GSK3 leading to an activation of ?
Localization (receptors) of EP2
14) Confidence 0.27 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.79 Pain Relevance 0.03
In addition, DEX reduced the IL-1beta induced COX-2 immunoreactivity in the same concentration as wherein it inhibited PGE2 secretion.
Localization (secretion) of PGE2 associated with dexamethasone
15) Confidence 0.26 Published 2001 Journal Exp. Gerontol. Section Abstract Doc Link 11250126 Disease Relevance 0.75 Pain Relevance 0.45
B can be upregulated due to reactive oxygen species release and inflammation (i.e., PGE2).
Localization (release) of PGE2 associated with inflammation and fever
16) Confidence 0.23 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.88 Pain Relevance 0.09
Finally, neither sodium nitroprusside nor zaprinast (both of which elevate cGMP levels) affected GM-CSF or PGE2 release.
Localization (release) of PGE2 in PGE2
17) Confidence 0.23 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15680249 Disease Relevance 0.05 Pain Relevance 0.87
In an assay to determine inhibition of the H2O2-activated release of PGE2, IL-6, and IL-8 in human normal fibroblast cell lines, the release of PGE2 and IL-6 was almost completely inhibited above concentrations of 0.05% and 1%, respectively.
Localization (release) of PGE2 in fibroblast
18) Confidence 0.18 Published 2008 Journal J Cosmet Sci Section Abstract Doc Link 18841306 Disease Relevance 0.26 Pain Relevance 0.10
In order to investigate the possibility of Crinum asiaticum Linne var. japonicum extract as a cosmetic ingredient, we measured its anti-inflammatory effect by its inhibition of iNOS (inducible nitric oxide synthase) and the release of PGE2, IL-6, and IL-8.
Localization (release) of PGE2 associated with inflammation
19) Confidence 0.18 Published 2008 Journal J Cosmet Sci Section Abstract Doc Link 18841306 Disease Relevance 0.60 Pain Relevance 0.21
In an assay to determine inhibition of the H2O2-activated release of PGE2, IL-6, and IL-8 in human normal fibroblast cell lines, the release of PGE2 and IL-6 was almost completely inhibited above concentrations of 0.05% and 1%, respectively.
Localization (release) of PGE2 in fibroblast
20) Confidence 0.18 Published 2008 Journal J Cosmet Sci Section Abstract Doc Link 18841306 Disease Relevance 0.25 Pain Relevance 0.10

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