INT35491

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Context Info
Confidence 0.61
First Reported 1985
Last Reported 2009
Negated 3
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.63
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aldh3a1) oxidoreductase activity (Aldh3a1) aging (Aldh3a1)
endoplasmic reticulum (Aldh3a1) cytoplasm (Aldh3a1)
Anatomy Link Frequency
aorta 1
Aldh3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 20 97.84 Very High Very High Very High
tolerance 6 91.44 High High
anesthesia 3 89.52 High High
cINOD 2 89.52 High High
alcohol 1 77.76 Quite High
monoamine 1 77.60 Quite High
Central nervous system 1 75.00 Quite High
Inflammation 17 64.88 Quite High
Neurotransmitter 2 63.48 Quite High
Angina 1 36.72 Quite Low
Disease Link Frequency Relevance Heat
Stress 50 98.96 Very High Very High Very High
Increased Venous Pressure Under Development 4 98.86 Very High Very High Very High
INFLAMMATION 28 89.12 High High
Disease 31 55.48 Quite High
Myocardial Infarction 1 37.52 Quite Low
Cv General 3 Under Development 1 36.72 Quite Low
Apoptosis 12 28.84 Quite Low
Inflammatory Breast Neoplasms 34 5.00 Very Low Very Low Very Low
Premature Birth 19 5.00 Very Low Very Low Very Low
Death 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, ALDH3A1, CRP, and HPT were induced by BaP subacute treatment, whereas another type of ALDH inducer, phenobarbital, did not affect the levels of APPs or ALDH3A1, but did increase ALDH1A3 activity.
Neg (not) Regulation (affect) of ALDH3A1
1) Confidence 0.61 Published 2003 Journal Chem. Biol. Interact. Section Abstract Doc Link 12604189 Disease Relevance 0.09 Pain Relevance 0.21
Ether did not influence ALDH activities in vitro.
Neg (not) Regulation (influence) of ALDH
2) Confidence 0.48 Published 1985 Journal Pharmacology Section Abstract Doc Link 3160048 Disease Relevance 0 Pain Relevance 0.31
Treatment with cyanamide or propionaldehyde did not significantly inhibit 1,1-diethyl-2-hydroxy-2-nitrosohydrazine-mediated vasodilation in tolerant or nontolerant aorta, indicating that these ALDH inhibitors do not affect the downstream effectors of NO-induced vasodilation.
Neg (not) Regulation (affect) of ALDH in aorta associated with increased venous pressure under development
3) Confidence 0.38 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14573760 Disease Relevance 0.29 Pain Relevance 0.15
Previous work has demonstrated the enzyme ALDH to be highly sensitive to products of oxidative stress (Florang et al., 2007; Jinsmaa et al., 2009; Rees et al., 2007).
Regulation (sensitive) of ALDH associated with stress
4) Confidence 0.03 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.25 Pain Relevance 0.41

General Comments

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