INT35492

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Context Info
Confidence 0.46
First Reported 1985
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 1.34
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aldh3a1) oxidoreductase activity (Aldh3a1) aging (Aldh3a1)
endoplasmic reticulum (Aldh3a1) cytoplasm (Aldh3a1)
Anatomy Link Frequency
brain 1
Aldh3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 40 99.54 Very High Very High Very High
Inflammation 37 98.84 Very High Very High Very High
cINOD 3 96.92 Very High Very High Very High
anesthesia 4 95.08 Very High Very High Very High
ketamine 31 87.32 High High
alcohol 1 83.32 Quite High
Central nervous system 1 75.00 Quite High
monoamine 2 65.76 Quite High
Neurotransmitter 4 51.64 Quite High
tolerance 56 43.44 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 58 98.84 Very High Very High Very High
Body Weight 2 95.28 Very High Very High Very High
Anaemia 4 91.36 High High
Stress 104 90.52 High High
Disease 62 51.12 Quite High
Apoptosis 24 17.00 Low Low
Inflammatory Breast Neoplasms 68 5.00 Very Low Very Low Very Low
Premature Birth 38 5.00 Very Low Very Low Very Low
Death 36 5.00 Very Low Very Low Very Low
Sepsis 34 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phenobarbital and pentobarbital inhibited aldehyde dehydrogenase (ALDH) activities in vitro in a noncompetitive fashion; Ki were 29 and 37 mM, respectively.
Negative_regulation (inhibited) of ALDH
1) Confidence 0.46 Published 1985 Journal Pharmacology Section Abstract Doc Link 3160048 Disease Relevance 0 Pain Relevance 0.33
The 3MC-induced ALDH3c activity was significantly diminished by the co-administered anti-inflammatory agents.
Negative_regulation (diminished) of ALDH3c associated with inflammation
2) Confidence 0.44 Published 1998 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 10323327 Disease Relevance 0.48 Pain Relevance 0.47
The results showed a reduction in b.w., FI, Htc and Hb in the experimental group.
Negative_regulation (reduction) of Htc
3) Confidence 0.35 Published 2000 Journal Acta Odontol Latinoam Section Abstract Doc Link 15211926 Disease Relevance 0.47 Pain Relevance 0.13
SCHEME 1.Irreversible inactivation of ALDH-catalyzed GTN reduction.
Negative_regulation (reduction) of ALDH
4) Confidence 0.27 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0
One candidate
inactivating agent is nitroxyl (NO-), which has been proposed to be
a product of GTN metabolism
(31), and which was reported
to cause partially irreversible inhibition of ALDH, presumably by the
formation of sulfinamides
(32). 
Spec (partially) Negative_regulation (inhibition) of ALDH
5) Confidence 0.27 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0
Protection and Restoration of the Dehydrogenase Reaction by
Thiols—The inhibition of mitochondrial ALDH by isosorbide dinitrate
is completely reversed by ?
Negative_regulation (inhibition) of mitochondrial ALDH
6) Confidence 0.24 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0
Inhibition of yeast ALDH
by NO was almost completely prevented and largely reversed by DTT, whereas
?
Negative_regulation (Inhibition) of ALDH
7) Confidence 0.17 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0
Reductases can compensate for impaired ALDH activity, and indeed, treatment of dopaminergic PC6-3 cells with 4HNE yielded both an increase in (DOPAL) but also (DOPET), compared with control.
Negative_regulation (impaired) of ALDH
8) Confidence 0.07 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.21 Pain Relevance 0.30
Using models for DA metabolism such as rat brain mitochondria, rat striatal synaptosomes and PC6-3 cells, both 4HNE and MDA were found to disrupt DA catabolism via potent inhibition of ALDH but not MAO at physiologic concentrations, yielding a several-fold increase in the level of cellular DOPAL.
Negative_regulation (inhibition) of ALDH in brain associated with dopamine
9) Confidence 0.05 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.18 Pain Relevance 0.36

General Comments

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