INT354948

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.69
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Shank3) cytoplasm (Shank3)
Shank3 (Mus musculus)
Pain Link Frequency Relevance Heat
Neurobehavioral 12 99.64 Very High Very High Very High
long-term potentiation 69 67.28 Quite High
depression 21 62.44 Quite High
Pyramidal cell 9 35.72 Quite Low
imagery 15 25.00 Low Low
Glutamate receptor 12 25.00 Low Low
Glutamate 3 25.00 Low Low
nMDA receptor 6 5.00 Very Low Very Low Very Low
Hippocampus 6 5.00 Very Low Very Low Very Low
tetrodotoxin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 45 99.96 Very High Very High Very High
Autism 9 90.16 High High
Depression 21 62.44 Quite High
Targeted Disruption 21 57.84 Quite High
Asperger Syndrome 3 29.44 Quite Low
Schizophrenia 6 15.76 Low Low
Li-fraumeni Syndrome 18 5.00 Very Low Very Low Very Low
Cognitive Disorder 6 5.00 Very Low Very Low Very Low
Mental Disorders 6 5.00 Very Low Very Low Very Low
Aggression 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Careful analysis of the extent of the deletion in dozens of independent cases indicated the presence of a small "critical region" encompassing SHANK3 [21,22], providing the first line of evidence that a dysfunction in SHANK3 may be responsible for the neurobehavioral aspects of 22q13DS.
Spec (may) Regulation (responsible) of SHANK3 associated with neurobehavioral
1) Confidence 0.45 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0.39 Pain Relevance 0.08
Our study targeted the full-length reference Shank3.
Regulation (targeted) of Shank3
2) Confidence 0.27 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0 Pain Relevance 0
The reduced glutamatergic transmission that we observed in the Shank3 heterozygous mice represents an interesting therapeutic target in Shank3-haploinsufficiency syndromes.



Regulation (target) of Shank3-haploinsufficiency associated with syndrome
3) Confidence 0.24 Published 2010 Journal Mol Autism Section Abstract Doc Link PMC3019144 Disease Relevance 0.30 Pain Relevance 0.18

General Comments

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