INT354949

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Context Info
Confidence 0.70
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.45
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Shank3) cytoplasm (Shank3)
Anatomy Link Frequency
cerebellar granule cells 2
Shank3 (Mus musculus)
Pain Link Frequency Relevance Heat
Neurobehavioral 8 92.64 High High
long-term potentiation 46 6.80 Low Low
depression 14 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Glutamate receptor 8 5.00 Very Low Very Low Very Low
Pyramidal cell 6 5.00 Very Low Very Low Very Low
nMDA receptor 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
tetrodotoxin 2 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asperger Syndrome 2 97.84 Very High Very High Very High
Syndrome 30 97.36 Very High Very High Very High
Schizophrenia 4 82.00 Quite High
Targeted Disruption 14 59.20 Quite High
Autism 6 57.00 Quite High
Depression 14 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 12 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low
Mental Disorders 4 5.00 Very Low Very Low Very Low
Aggression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, overexpression of SHANK3 may also result in an ASD as evidenced by reports of Asperger syndrome in an individual with three copies of the SHANK3 locus [27].
Positive_regulation (overexpression) of Gene_expression (overexpression) of SHANK3 associated with asperger syndrome
1) Confidence 0.70 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0.45 Pain Relevance 0.08
Transfection of Shank3 into aspiny cerebellar granule cells has been shown to induce an increase in the AMPA component of mEPSCs [19], and Shank3 is colocalized with GluR1-containing AMPA receptor in typical spines [53].
Positive_regulation (Transfection) of Gene_expression (Transfection) of Shank3 in cerebellar granule cells
2) Confidence 0.44 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0 Pain Relevance 0

General Comments

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