INT354953

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.36
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Shank3) cytoplasm (Shank3)
Anatomy Link Frequency
neurons 2
Shank3 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 8 35.76 Quite Low
Neurobehavioral 8 28.72 Quite Low
long-term potentiation 46 5.00 Very Low Very Low Very Low
depression 14 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Pyramidal cell 6 5.00 Very Low Very Low Very Low
nMDA receptor 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
tetrodotoxin 2 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 14 93.36 High High
Syndrome 30 73.60 Quite High
Autism 6 51.60 Quite High
Depression 14 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 12 5.00 Very Low Very Low Very Low
Schizophrenia 4 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low
Mental Disorders 4 5.00 Very Low Very Low Very Low
Aggression 2 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, inhibition of Shank3 expression has been shown to reduce numbers of spines in hippocampal neurons in culture and, conversely, when Shank3 was introduced into aspiny cerebellar neurons in vitro, the neurons developed spines with functional glutamatergic synapses expressing NMDA, AMPA and mGlu receptors [19].


Negative_regulation (inhibition) of Gene_expression (expression) of Shank3 in neurons
1) Confidence 0.59 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0.36 Pain Relevance 0
Synaptic development and function in Shank3 heterozygotes
Negative_regulation (development) of Gene_expression (heterozygotes) of Shank3
2) Confidence 0.43 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox