INT354956

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) transport (Gria1) endoplasmic reticulum (Gria1)
plasma membrane (Gria1) protein complex (Gria1)
Gria1 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 23 31.04 Quite Low
depression 7 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Neurobehavioral 4 5.00 Very Low Very Low Very Low
Glutamate receptor 4 5.00 Very Low Very Low Very Low
Pyramidal cell 3 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autism 3 50.00 Quite Low
Syndrome 15 5.00 Very Low Very Low Very Low
Depression 7 5.00 Very Low Very Low Very Low
Targeted Disruption 7 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 6 5.00 Very Low Very Low Very Low
Schizophrenia 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Mental Disorders 2 5.00 Very Low Very Low Very Low
Aggression 1 5.00 Very Low Very Low Very Low
Shock 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our studies, haploinsufficiency of Shank3 in vivo leads to reduced levels of AMPA receptors and GluR1-positive puncta, results which are consistent with such studies in vitro.
Negative_regulation (reduced) of Localization (levels) of GluR1
1) Confidence 0.26 Published 2010 Journal Mol Autism Section Body Doc Link PMC3019144 Disease Relevance 0 Pain Relevance 0

General Comments

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